ID   DFB17_RAT               Reviewed;          65 AA.
AC   Q32ZH5;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Beta-defensin 17;
DE            Short=BD-17;
DE   AltName: Full=Defensin, beta 17;
DE   Flags: Precursor;
GN   Name=Defb17;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT51887.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY621348; AAT51887.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001032623.1; NM_001037534.1.
DR   AlphaFoldDB; Q32ZH5; -.
DR   SMR; Q32ZH5; -.
DR   STRING; 10116.ENSRNOP00000057521; -.
DR   PaxDb; Q32ZH5; -.
DR   GeneID; 641658; -.
DR   KEGG; rno:641658; -.
DR   UCSC; RGD:1565718; rat.
DR   CTD; 641658; -.
DR   RGD; 1565718; Defb17.
DR   eggNOG; ENOG502TGN0; Eukaryota.
DR   InParanoid; Q32ZH5; -.
DR   OrthoDB; 1610592at2759; -.
DR   PhylomeDB; Q32ZH5; -.
DR   PRO; PR:Q32ZH5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..65
FT                   /note="Beta-defensin 17"
FT                   /id="PRO_0000352702"
FT   DISULFID        35..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..64
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   65 AA;  7598 MW;  1624464C35274B9C CRC64;
     MKFHLLFFIL LFSITILTGK RSYPEYGSLD LRKECRMSKG HCKLQCSENE IRIAFCIRPG
     THCCI