ID   DFB18_MOUSE             Reviewed;          85 AA.
AC   Q30KP5;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Beta-defensin 18;
DE            Short=BD-18;
DE            Short=mBD-18;
DE   AltName: Full=Defensin, beta 18;
DE   Flags: Precursor;
GN   Name=Defb18;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012029; AAY59765.1; -; mRNA.
DR   CCDS; CCDS35520.1; -.
DR   RefSeq; NP_001034212.1; NM_001039123.1.
DR   AlphaFoldDB; Q30KP5; -.
DR   STRING; 10090.ENSMUSP00000095427; -.
DR   iPTMnet; Q30KP5; -.
DR   PhosphoSitePlus; Q30KP5; -.
DR   jPOST; Q30KP5; -.
DR   PaxDb; Q30KP5; -.
DR   PRIDE; Q30KP5; -.
DR   Antibodypedia; 64300; 5 antibodies from 1 providers.
DR   DNASU; 654460; -.
DR   Ensembl; ENSMUST00000097818; ENSMUSP00000095427; ENSMUSG00000073735.
DR   GeneID; 654460; -.
DR   KEGG; mmu:654460; -.
DR   UCSC; uc007akm.1; mouse.
DR   CTD; 654460; -.
DR   MGI; MGI:3648148; Defb18.
DR   VEuPathDB; HostDB:ENSMUSG00000073735; -.
DR   eggNOG; ENOG502TEDM; Eukaryota.
DR   GeneTree; ENSGT00400000023306; -.
DR   HOGENOM; CLU_169780_0_0_1; -.
DR   InParanoid; Q30KP5; -.
DR   OMA; GACKPEC; -.
DR   OrthoDB; 1541529at2759; -.
DR   PhylomeDB; Q30KP5; -.
DR   Reactome; R-MMU-1461957; Beta defensins.
DR   Reactome; R-MMU-1461973; Defensins.
DR   BioGRID-ORCS; 654460; 3 hits in 71 CRISPR screens.
DR   PRO; PR:Q30KP5; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q30KP5; protein.
DR   Bgee; ENSMUSG00000073735; Expressed in hypothalamus and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..85
FT                   /note="Beta-defensin 18"
FT                   /id="PRO_0000352703"
FT   DISULFID        39..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..66
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   85 AA;  9887 MW;  99D7ED55D41D97D6 CRC64;
     MQSTMKMFGI ILMVIFSVSC GPSAPQMKTR EVAERTHKCS LVRGTCKSEC NSWEYKYNYC
     HTEPCCVVRE YKRMEKLLST PKYTT