DFB19_MOUSE
ID DFB19_MOUSE Reviewed; 83 AA.
AC Q8K3I8; Q3V0L7;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Beta-defensin 19;
DE Short=BD-19;
DE Short=mBD-19;
DE AltName: Full=Defensin, beta 19;
DE AltName: Full=Testis-specific beta-defensin-like protein;
DE Flags: Precursor;
GN Name=Defb19; Synonyms=Defb24, Tdl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6 X DBA/2;
RX PubMed=12128228; DOI=10.1016/s0925-4773(02)00144-2;
RA Yamamoto M., Matsui Y.;
RT "Testis-specific expression of a novel mouse defensin-like gene, Tdl.";
RL Mech. Dev. 116:217-221(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=12617826; DOI=10.1016/s1567-133x(02)00022-4;
RA Menke D.B., Page D.C.;
RT "Sexually dimorphic gene expression in the developing mouse gonad.";
RL Gene Expr. Patterns 2:359-367(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in male gonads (Sertoli
CC cells). {ECO:0000269|PubMed:12128228}.
CC -!- DEVELOPMENTAL STAGE: Not detected at 11.5 dpc. Specific signals are
CC observed within seminiferous cords in male gonads at 12.5, 13.5, 14.5,
CC and 16.5 dpc and in newborn testes. In 16.5 and newborn testes, its
CC expression is also found in epididymis. No specific signal is found in
CC female gonads. {ECO:0000269|PubMed:12128228}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY098993; AAM28243.1; -; mRNA.
DR EMBL; AF532614; AAO27571.1; -; mRNA.
DR EMBL; DQ012035; AAY59771.1; -; mRNA.
DR EMBL; AK133049; BAE21487.1; -; mRNA.
DR EMBL; AL845162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049701; AAH49701.1; -; mRNA.
DR CCDS; CCDS38277.1; -.
DR RefSeq; NP_660139.1; NM_145157.3.
DR AlphaFoldDB; Q8K3I8; -.
DR STRING; 10090.ENSMUSP00000059585; -.
DR PaxDb; Q8K3I8; -.
DR PRIDE; Q8K3I8; -.
DR ProteomicsDB; 279636; -.
DR DNASU; 246700; -.
DR Ensembl; ENSMUST00000053180; ENSMUSP00000059585; ENSMUSG00000050645.
DR GeneID; 246700; -.
DR KEGG; mmu:246700; -.
DR UCSC; uc008nfs.1; mouse.
DR CTD; 246700; -.
DR MGI; MGI:2385955; Defb19.
DR VEuPathDB; HostDB:ENSMUSG00000050645; -.
DR eggNOG; ENOG502TDXM; Eukaryota.
DR GeneTree; ENSGT00510000050451; -.
DR HOGENOM; CLU_193927_0_0_1; -.
DR InParanoid; Q8K3I8; -.
DR OMA; HHTLRCM; -.
DR OrthoDB; 1571101at2759; -.
DR PhylomeDB; Q8K3I8; -.
DR Reactome; R-MMU-1461957; Beta defensins.
DR Reactome; R-MMU-1461973; Defensins.
DR BioGRID-ORCS; 246700; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8K3I8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8K3I8; protein.
DR Bgee; ENSMUSG00000050645; Expressed in gonadal ridge and 31 other tissues.
DR Genevisible; Q8K3I8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001530; F:lipopolysaccharide binding; ISO:MGI.
DR GO; GO:0061760; P:antifungal innate immune response; ISO:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR InterPro; IPR028060; Defensin_big_dom.
DR Pfam; PF14862; Defensin_big; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PEPTIDE 20..83
FT /note="Beta-defensin 19"
FT /id="PRO_0000006944"
FT DISULFID 27..54
FT /evidence="ECO:0000250"
FT DISULFID 34..48
FT /evidence="ECO:0000250"
FT DISULFID 38..55
FT /evidence="ECO:0000250"
SQ SEQUENCE 83 AA; 9568 MW; 9D7B69BD9AA30B98 CRC64;
MRLALLLLAI LVATELVVSG KNPILQCMGN RGFCRSSCKK SEQAYFYCRT FQMCCLQSYV
RISLTGVDDN TNWSYEKHWP RIP
