DFB20_MOUSE
ID DFB20_MOUSE Reviewed; 96 AA.
AC Q30KP3; Q8C5A7;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Beta-defensin 20;
DE Short=BD-20;
DE Short=mBD-20;
DE AltName: Full=Defensin, beta 20;
DE Flags: Precursor;
GN Name=Defb20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC37500.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DQ012031; AAY59767.1; -; mRNA.
DR EMBL; AK079000; BAC37500.1; ALT_INIT; mRNA.
DR EMBL; AL844517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38275.1; -.
DR RefSeq; NP_795924.2; NM_176950.3.
DR AlphaFoldDB; Q30KP3; -.
DR SMR; Q30KP3; -.
DR STRING; 10090.ENSMUSP00000105462; -.
DR PaxDb; Q30KP3; -.
DR PRIDE; Q30KP3; -.
DR ProteomicsDB; 279520; -.
DR DNASU; 319579; -.
DR Ensembl; ENSMUST00000109836; ENSMUSP00000105462; ENSMUSG00000049560.
DR GeneID; 319579; -.
DR KEGG; mmu:319579; -.
DR UCSC; uc008nfm.1; mouse.
DR CTD; 319579; -.
DR MGI; MGI:2442320; Defb20.
DR VEuPathDB; HostDB:ENSMUSG00000049560; -.
DR eggNOG; ENOG502TM18; Eukaryota.
DR GeneTree; ENSGT00530000064329; -.
DR HOGENOM; CLU_2399087_0_0_1; -.
DR InParanoid; Q30KP3; -.
DR OMA; ISEMGCL; -.
DR OrthoDB; 1568261at2759; -.
DR PhylomeDB; Q30KP3; -.
DR BioGRID-ORCS; 319579; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q30KP3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q30KP3; protein.
DR Bgee; ENSMUSG00000049560; Expressed in ovary and 2 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..96
FT /note="Beta-defensin 20"
FT /id="PRO_0000352705"
FT DISULFID 24..52
FT /evidence="ECO:0000250"
FT DISULFID 32..46
FT /evidence="ECO:0000250"
FT DISULFID 36..53
FT /evidence="ECO:0000250"
SQ SEQUENCE 96 AA; 11039 MW; 7D2EC83872FB0FAA CRC64;
MKLLQVLLVL LFVALADGAQ PKRCFSNVEG YCRKKCRLVE ISEMGCLHGK YCCVNELENK
KHKKHSVVEE TVKLQDKSKV QDYMILPTVT YYTISI
