ID   DFB25_MOUSE             Reviewed;          71 AA.
AC   Q30KN8;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Beta-defensin 25;
DE            Short=BD-25;
DE            Short=mBD-25;
DE   AltName: Full=Defensin, beta 25;
DE   Flags: Precursor;
GN   Name=Defb25;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012036; AAY59772.1; -; mRNA.
DR   EMBL; AL845162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC132662; AAI32663.1; -; mRNA.
DR   CCDS; CCDS38280.1; -.
DR   RefSeq; NP_001034211.1; NM_001039122.1.
DR   AlphaFoldDB; Q30KN8; -.
DR   SMR; Q30KN8; -.
DR   STRING; 10090.ENSMUSP00000096809; -.
DR   PaxDb; Q30KN8; -.
DR   PRIDE; Q30KN8; -.
DR   ProteomicsDB; 279521; -.
DR   Antibodypedia; 62850; 40 antibodies from 6 providers.
DR   Ensembl; ENSMUST00000099203; ENSMUSP00000096809; ENSMUSG00000074678.
DR   GeneID; 654459; -.
DR   KEGG; mmu:654459; -.
DR   UCSC; uc008nfv.1; mouse.
DR   CTD; 654459; -.
DR   MGI; MGI:3651158; Defb25.
DR   VEuPathDB; HostDB:ENSMUSG00000074678; -.
DR   eggNOG; ENOG502TF15; Eukaryota.
DR   GeneTree; ENSGT00530000064308; -.
DR   HOGENOM; CLU_181906_4_0_1; -.
DR   InParanoid; Q30KN8; -.
DR   OMA; FMHLCPD; -.
DR   OrthoDB; 1608867at2759; -.
DR   PhylomeDB; Q30KN8; -.
DR   Reactome; R-MMU-1461957; Beta defensins.
DR   Reactome; R-MMU-1461973; Defensins.
DR   BioGRID-ORCS; 654459; 1 hit in 71 CRISPR screens.
DR   PRO; PR:Q30KN8; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q30KN8; protein.
DR   Bgee; ENSMUSG00000074678; Expressed in white adipose tissue and 35 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0071224; P:cellular response to peptidoglycan; ISO:MGI.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:MGI.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; ISO:MGI.
DR   GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; ISO:MGI.
DR   GO; GO:0032722; P:positive regulation of chemokine production; ISO:MGI.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:MGI.
DR   GO; GO:0032743; P:positive regulation of interleukin-2 production; ISO:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:MGI.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISO:MGI.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..71
FT                   /note="Beta-defensin 25"
FT                   /id="PRO_0000352707"
FT   DISULFID        27..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  7961 MW;  7C93A77E2CE018DA CRC64;
     MAKWILLIVA LLVLSHVPPG STEFKRCWNG QGACRTFCTR QETFMHLCPD ASLCCLSYSF
     KPSRPSRVGD V