ID   DFB25_RAT               Reviewed;          71 AA.
AC   Q32ZG7;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Beta-defensin 25;
DE            Short=BD-25;
DE   AltName: Full=Defensin, beta 25;
DE   Flags: Precursor;
GN   Name=Defb25;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621356; AAT51895.1; -; mRNA.
DR   RefSeq; NP_001032605.1; NM_001037516.1.
DR   AlphaFoldDB; Q32ZG7; -.
DR   SMR; Q32ZG7; -.
DR   STRING; 10116.ENSRNOP00000052274; -.
DR   PaxDb; Q32ZG7; -.
DR   Ensembl; ENSRNOT00000055406; ENSRNOP00000052274; ENSRNOG00000036895.
DR   GeneID; 641644; -.
DR   KEGG; rno:641644; -.
DR   UCSC; RGD:1564765; rat.
DR   CTD; 654459; -.
DR   RGD; 1564765; Defb25.
DR   eggNOG; ENOG502TF15; Eukaryota.
DR   GeneTree; ENSGT00530000064308; -.
DR   HOGENOM; CLU_181906_4_0_1; -.
DR   InParanoid; Q32ZG7; -.
DR   OMA; FMHLCPD; -.
DR   OrthoDB; 1608867at2759; -.
DR   PhylomeDB; Q32ZG7; -.
DR   Reactome; R-RNO-1461957; Beta defensins.
DR   Reactome; R-RNO-1461973; Defensins.
DR   PRO; PR:Q32ZG7; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000036895; Expressed in colon and 8 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0071224; P:cellular response to peptidoglycan; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IBA:GO_Central.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IBA:GO_Central.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..71
FT                   /note="Beta-defensin 25"
FT                   /id="PRO_0000352708"
FT   DISULFID        27..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  7781 MW;  F1907585E9CA8CED CRC64;
     MAKWILLIVA LLVLGHVPSG STEFKRCWNG QGACRTYCTR QEKFIHLCPD ASLCCLSYSL
     KASPHSRAGG V