DFB29_MOUSE
ID DFB29_MOUSE Reviewed; 78 AA.
AC Q8BGW9;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Beta-defensin 29;
DE Short=BD-29;
DE Short=mBD-29;
DE AltName: Full=Defensin, beta 29;
DE Flags: Precursor;
GN Name=Defb29;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RA Conejo-Garcia J.R., Benencia F., Zhang L., Courreges C., Khang E.,
RA Mohamed-Hadley A., Gray H., Coukos G.;
RT "Immature dendritic cells recruited by defensins contribute to
RT neoangiogenesis and ovarian cancer progression in the presence of VEGF.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=23765988; DOI=10.1002/jcp.24418;
RA Caballero-Campo P., Buffone M.G., Benencia F., Conejo-Garcia J.R.,
RA Rinaudo P.F., Gerton G.L.;
RT "A role for the chemokine receptor CCR6 in mammalian sperm motility and
RT chemotaxis.";
RL J. Cell. Physiol. 229:68-78(2014).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the cauda epididymis.
CC {ECO:0000269|PubMed:23765988}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF515626; AAN77095.1; -; mRNA.
DR EMBL; AK002707; BAC25003.1; -; mRNA.
DR CCDS; CCDS38276.1; -.
DR RefSeq; NP_001001444.1; NM_001001444.2.
DR AlphaFoldDB; Q8BGW9; -.
DR SMR; Q8BGW9; -.
DR STRING; 10090.ENSMUSP00000052589; -.
DR PhosphoSitePlus; Q8BGW9; -.
DR PaxDb; Q8BGW9; -.
DR PeptideAtlas; Q8BGW9; -.
DR PRIDE; Q8BGW9; -.
DR ProteomicsDB; 279522; -.
DR Antibodypedia; 49711; 8 antibodies from 6 providers.
DR Ensembl; ENSMUST00000060598; ENSMUSP00000052589; ENSMUSG00000044249.
DR GeneID; 75400; -.
DR KEGG; mmu:75400; -.
DR UCSC; uc008nfq.1; mouse.
DR CTD; 75400; -.
DR MGI; MGI:1922650; Defb29.
DR VEuPathDB; HostDB:ENSMUSG00000044249; -.
DR eggNOG; ENOG502TF8H; Eukaryota.
DR GeneTree; ENSGT00390000001502; -.
DR HOGENOM; CLU_2482789_0_0_1; -.
DR InParanoid; Q8BGW9; -.
DR OMA; NACRKYE; -.
DR OrthoDB; 1588126at2759; -.
DR PhylomeDB; Q8BGW9; -.
DR BioGRID-ORCS; 75400; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Defb29; mouse.
DR PRO; PR:Q8BGW9; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BGW9; protein.
DR Bgee; ENSMUSG00000044249; Expressed in right kidney and 21 other tissues.
DR ExpressionAtlas; Q8BGW9; baseline and differential.
DR Genevisible; Q8BGW9; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..78
FT /note="Beta-defensin 29"
FT /id="PRO_0000006945"
FT DISULFID 40..67
FT /evidence="ECO:0000250"
FT DISULFID 47..61
FT /evidence="ECO:0000250"
FT DISULFID 51..68
FT /evidence="ECO:0000250"
SQ SEQUENCE 78 AA; 9067 MW; 6834B02E68524C32 CRC64;
MPVTKSYFMT VVVVLILVDE TTGGLFGFRS SKRQEPWIAC ELYQGLCRNA CQKYEIQYLS
CPKTRKCCLK YPRKITSF
