DFB30_MOUSE
ID DFB30_MOUSE Reviewed; 75 AA.
AC Q30KN4;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Beta-defensin 30;
DE Short=BD-30;
DE Short=mBD-30;
DE AltName: Full=Defensin, beta 30;
DE Flags: Precursor;
GN Name=Defb30;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Epididymis;
RA Radhakrishnan Y., Yenugu S., Hamil K.G., French F.S., Hall S.H.;
RT "Male reproductive tract specific rodent beta defensins.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012040; AAY59776.1; -; mRNA.
DR EMBL; DQ141309; ABA26845.1; -; mRNA.
DR EMBL; BC132184; AAI32185.1; -; mRNA.
DR EMBL; BC132214; AAI32215.1; -; mRNA.
DR CCDS; CCDS36947.1; -.
DR RefSeq; NP_001034655.1; NM_001039566.2.
DR AlphaFoldDB; Q30KN4; -.
DR SMR; Q30KN4; -.
DR STRING; 10090.ENSMUSP00000106838; -.
DR PaxDb; Q30KN4; -.
DR PRIDE; Q30KN4; -.
DR ProteomicsDB; 279637; -.
DR Antibodypedia; 50843; 5 antibodies from 1 providers.
DR Ensembl; ENSMUST00000100490; ENSMUSP00000098059; ENSMUSG00000075571.
DR Ensembl; ENSMUST00000111207; ENSMUSP00000106838; ENSMUSG00000075571.
DR GeneID; 73670; -.
DR KEGG; mmu:73670; -.
DR UCSC; uc007uhd.2; mouse.
DR CTD; 73670; -.
DR MGI; MGI:1920920; Defb30.
DR VEuPathDB; HostDB:ENSMUSG00000075571; -.
DR eggNOG; ENOG502TF02; Eukaryota.
DR GeneTree; ENSGT00530000064429; -.
DR HOGENOM; CLU_181906_3_0_1; -.
DR InParanoid; Q30KN4; -.
DR OMA; NTCWRTK; -.
DR OrthoDB; 1613766at2759; -.
DR PhylomeDB; Q30KN4; -.
DR Reactome; R-MMU-1461957; Beta defensins.
DR Reactome; R-MMU-1461973; Defensins.
DR BioGRID-ORCS; 73670; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q30KN4; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q30KN4; protein.
DR Bgee; ENSMUSG00000075571; Expressed in spermatid and 13 other tissues.
DR ExpressionAtlas; Q30KN4; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..75
FT /note="Beta-defensin 30"
FT /id="PRO_0000352710"
FT DISULFID 35..62
FT /evidence="ECO:0000250"
FT DISULFID 42..56
FT /evidence="ECO:0000250"
FT DISULFID 46..63
FT /evidence="ECO:0000250"
SQ SEQUENCE 75 AA; 8734 MW; 60241261261D9836 CRC64;
MGSLQLTLVL FVLLSYVPPV RSGVNMYIKR IYDTCWKLKG ICRNTCQKEE IYHIFCGIQS
LCCLEKKEMP VLFVK
