ID   DFB30_RAT               Reviewed;          75 AA.
AC   Q32ZG2;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Beta-defensin 30;
DE            Short=BD-30;
DE   AltName: Full=Defensin, beta 30;
DE   Flags: Precursor;
GN   Name=Defb30;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Epididymis;
RX   PubMed=16457734; DOI=10.1186/1477-7827-4-7;
RA   Yenugu S., Chintalgattu V., Wingard C.J., Radhakrishnan Y., French F.S.,
RA   Hall S.H.;
RT   "Identification, cloning and functional characterization of novel beta-
RT   defensins in the rat (Rattus norvegicus).";
RL   Reprod. Biol. Endocrinol. 4:7-7(2006).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621361; AAT51900.1; -; mRNA.
DR   EMBL; AY600146; AAU04550.1; -; mRNA.
DR   RefSeq; NP_001032620.1; NM_001037531.1.
DR   RefSeq; XP_008768998.1; XM_008770776.1.
DR   AlphaFoldDB; Q32ZG2; -.
DR   SMR; Q32ZG2; -.
DR   STRING; 10116.ENSRNOP00000055981; -.
DR   PaxDb; Q32ZG2; -.
DR   Ensembl; ENSRNOT00000059211; ENSRNOP00000055981; ENSRNOG00000038758.
DR   GeneID; 641656; -.
DR   KEGG; rno:641656; -.
DR   UCSC; RGD:1559641; rat.
DR   CTD; 73670; -.
DR   RGD; 1559641; Defb30.
DR   eggNOG; ENOG502TF02; Eukaryota.
DR   GeneTree; ENSGT00530000064429; -.
DR   HOGENOM; CLU_181906_3_0_1; -.
DR   InParanoid; Q32ZG2; -.
DR   OMA; NTCWRTK; -.
DR   OrthoDB; 1613766at2759; -.
DR   PhylomeDB; Q32ZG2; -.
DR   Reactome; R-RNO-1461957; Beta defensins.
DR   Reactome; R-RNO-1461973; Defensins.
DR   PRO; PR:Q32ZG2; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..75
FT                   /note="Beta-defensin 30"
FT                   /id="PRO_0000352711"
FT   DISULFID        35..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..63
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   75 AA;  8708 MW;  84600A03982EEC1C CRC64;
     MGSLQLILVL FVLLSDVPPV RSGVNMYIRQ IYDTCWKLKG HCRNVCGKKE IFHIFCGTQF
     LCCIERKEMP VLFVK