DFB33_MOUSE
ID DFB33_MOUSE Reviewed; 62 AA.
AC Q30KN3;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Beta-defensin 33;
DE Short=BD-33;
DE Short=mBD-33;
DE AltName: Full=Defensin, beta 33;
DE Flags: Precursor;
GN Name=Defb33;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012041; AAY59777.1; -; mRNA.
DR EMBL; BC145764; AAI45765.1; -; mRNA.
DR EMBL; BC145766; AAI45767.1; -; mRNA.
DR CCDS; CCDS57609.1; -.
DR RefSeq; NP_001034208.1; NM_001039119.2.
DR AlphaFoldDB; Q30KN3; -.
DR SMR; Q30KN3; -.
DR STRING; 10090.ENSMUSP00000096507; -.
DR PaxDb; Q30KN3; -.
DR PRIDE; Q30KN3; -.
DR Ensembl; ENSMUST00000098908; ENSMUSP00000096507; ENSMUSG00000074454.
DR GeneID; 654453; -.
DR KEGG; mmu:654453; -.
DR UCSC; uc009oah.2; mouse.
DR CTD; 654453; -.
DR MGI; MGI:3647176; Defb33.
DR VEuPathDB; HostDB:ENSMUSG00000074454; -.
DR eggNOG; ENOG502TDWQ; Eukaryota.
DR GeneTree; ENSGT00400000023630; -.
DR HOGENOM; CLU_2921888_0_0_1; -.
DR InParanoid; Q30KN3; -.
DR OMA; RYKHCCR; -.
DR OrthoDB; 1618525at2759; -.
DR PhylomeDB; Q30KN3; -.
DR BioGRID-ORCS; 654453; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q30KN3; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q30KN3; protein.
DR Bgee; ENSMUSG00000074454; Expressed in testis and 7 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..62
FT /note="Beta-defensin 33"
FT /id="PRO_0000352712"
FT DISULFID 30..59
FT /evidence="ECO:0000250"
FT DISULFID 37..52
FT /evidence="ECO:0000250"
FT DISULFID 45..60
FT /evidence="ECO:0000250"
SQ SEQUENCE 62 AA; 7105 MW; DF69F8BCB1DC85BA CRC64;
MRLLFLLFIL LVCLAQTTSG RKRNSKFRPC EKMGGICKSQ KTHGCSILPA ECKSRYKHCC
RL
