ID   DFB33_RAT               Reviewed;          62 AA.
AC   Q32ZG1;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Beta-defensin 33;
DE            Short=BD-33;
DE   AltName: Full=Defensin, beta 33;
DE   Flags: Precursor;
GN   Name=Defb33;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621362; AAT51901.1; -; mRNA.
DR   RefSeq; NP_001032612.1; NM_001037523.1.
DR   AlphaFoldDB; Q32ZG1; -.
DR   SMR; Q32ZG1; -.
DR   STRING; 10116.ENSRNOP00000054840; -.
DR   PaxDb; Q32ZG1; -.
DR   PRIDE; Q32ZG1; -.
DR   GeneID; 641647; -.
DR   KEGG; rno:641647; -.
DR   UCSC; RGD:1562959; rat.
DR   CTD; 654453; -.
DR   RGD; 1562959; Defb33.
DR   VEuPathDB; HostDB:ENSRNOG00000038128; -.
DR   eggNOG; ENOG502TDWQ; Eukaryota.
DR   HOGENOM; CLU_2921888_0_0_1; -.
DR   InParanoid; Q32ZG1; -.
DR   OMA; RYKHCCR; -.
DR   OrthoDB; 1618525at2759; -.
DR   PhylomeDB; Q32ZG1; -.
DR   PRO; PR:Q32ZG1; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000038128; Expressed in testis.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..62
FT                   /note="Beta-defensin 33"
FT                   /id="PRO_0000352713"
FT   DISULFID        30..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   62 AA;  7253 MW;  F01753A601C721E6 CRC64;
     MRLLFLLFLL LVCLAQKTSG RKRNTKFRQC EKMGGICKYQ KTHGCSILPA ECKSRYKHCC
     RL