DFB34_MOUSE
ID DFB34_MOUSE Reviewed; 81 AA.
AC Q7TNV8;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Beta-defensin 34;
DE Short=BD-34;
DE Short=mBD-34;
DE AltName: Full=Defensin, beta 34;
DE Flags: Precursor;
GN Name=Defb34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Maxwell A., Dorin J.R.;
RT "Amino acid residues subject to positive selection in murine beta-defensin
RT antimicrobial peptides.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Epididymis;
RX PubMed=14718547; DOI=10.1074/jbc.m307697200;
RA Zaballos A., Villares R., Albar J.P., Martinez-A C., Marquez G.;
RT "Identification on mouse chromosome 8 of new beta-defensin genes with
RT regionally specific expression in the male reproductive organ.";
RL J. Biol. Chem. 279:12421-12426(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Only expressed in epididymis (caput, corpus and
CC cauda). {ECO:0000269|PubMed:14718547}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ578469; CAE17666.1; -; mRNA.
DR CCDS; CCDS52497.1; -.
DR RefSeq; NP_898856.1; NM_183035.1.
DR AlphaFoldDB; Q7TNV8; -.
DR SMR; Q7TNV8; -.
DR STRING; 10090.ENSMUSP00000064554; -.
DR PaxDb; Q7TNV8; -.
DR PRIDE; Q7TNV8; -.
DR DNASU; 360211; -.
DR Ensembl; ENSMUST00000064475; ENSMUSP00000064554; ENSMUSG00000052554.
DR GeneID; 360211; -.
DR KEGG; mmu:360211; -.
DR UCSC; uc009lad.1; mouse.
DR CTD; 360211; -.
DR MGI; MGI:2672979; Defb34.
DR VEuPathDB; HostDB:ENSMUSG00000052554; -.
DR eggNOG; ENOG502TF62; Eukaryota.
DR GeneTree; ENSGT00950000183398; -.
DR HOGENOM; CLU_187814_0_0_1; -.
DR InParanoid; Q7TNV8; -.
DR OrthoDB; 1629258at2759; -.
DR PhylomeDB; Q7TNV8; -.
DR BioGRID-ORCS; 360211; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q7TNV8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q7TNV8; protein.
DR Bgee; ENSMUSG00000052554; Expressed in granulocyte.
DR GO; GO:0019898; C:extrinsic component of membrane; ISO:MGI.
DR GO; GO:1990742; C:microvesicle; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0031727; F:CCR2 chemokine receptor binding; ISO:MGI.
DR GO; GO:0008201; F:heparin binding; ISO:MGI.
DR GO; GO:0001530; F:lipopolysaccharide binding; ISO:MGI.
DR GO; GO:0061760; P:antifungal innate immune response; ISO:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..81
FT /note="Beta-defensin 34"
FT /id="PRO_0000006946"
FT REGION 62..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 28..55
FT /evidence="ECO:0000250"
FT DISULFID 35..49
FT /evidence="ECO:0000250"
FT DISULFID 39..56
FT /evidence="ECO:0000250"
SQ SEQUENCE 81 AA; 9268 MW; 66AA6C636A287614 CRC64;
MKTFLFLFAV LFFWSQPRMH FFFFDEKCSR INGRCTASCL KNEELVALCW KNLKCCVTVQ
SCGRSKGNQS DEGSGHMGTR G
