DFB35_MOUSE
ID DFB35_MOUSE Reviewed; 63 AA.
AC Q8R2I3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Beta-defensin 35;
DE Short=BD-35;
DE Short=mBD-35;
DE AltName: Full=Defensin, beta 35;
DE Flags: Precursor;
GN Name=Defb35;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6N; TISSUE=Testis;
RX PubMed=12644567; DOI=10.1093/molbev/msg060;
RA Morrison G.M., Semple C.A.M., Kilanowski F.M., Hill R.E., Dorin J.R.;
RT "Signal sequence conservation and mature peptide divergence within
RT subgroups of the murine beta-defensin gene family.";
RL Mol. Biol. Evol. 20:460-470(2003).
RN [2]
RP TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Epididymis;
RX PubMed=14718547; DOI=10.1074/jbc.m307697200;
RA Zaballos A., Villares R., Albar J.P., Martinez-A C., Marquez G.;
RT "Identification on mouse chromosome 8 of new beta-defensin genes with
RT regionally specific expression in the male reproductive organ.";
RL J. Biol. Chem. 279:12421-12426(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in testis, epididymis (caput, corpus and
CC cauda), kidney and neonatal and adult brain.
CC {ECO:0000269|PubMed:12644567, ECO:0000269|PubMed:14718547}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ437650; CAD26899.1; -; mRNA.
DR CCDS; CCDS52516.1; -.
DR RefSeq; NP_631970.1; NM_139224.1.
DR AlphaFoldDB; Q8R2I3; -.
DR SMR; Q8R2I3; -.
DR STRING; 10090.ENSMUSP00000076067; -.
DR PaxDb; Q8R2I3; -.
DR PRIDE; Q8R2I3; -.
DR DNASU; 246084; -.
DR Ensembl; ENSMUST00000076786; ENSMUSP00000076067; ENSMUSG00000058052.
DR GeneID; 246084; -.
DR KEGG; mmu:246084; -.
DR UCSC; uc009lcf.1; mouse.
DR CTD; 246084; -.
DR MGI; MGI:2179204; Defb35.
DR VEuPathDB; HostDB:ENSMUSG00000058052; -.
DR GeneTree; ENSGT00390000002317; -.
DR HOGENOM; CLU_197691_0_0_1; -.
DR InParanoid; Q8R2I3; -.
DR OMA; GSCKQSM; -.
DR OrthoDB; 1579011at2759; -.
DR PhylomeDB; Q8R2I3; -.
DR BioGRID-ORCS; 246084; 1 hit in 39 CRISPR screens.
DR PRO; PR:Q8R2I3; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R2I3; protein.
DR Bgee; ENSMUSG00000058052; Expressed in submandibular gland and 17 other tissues.
DR Genevisible; Q8R2I3; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..63
FT /note="Beta-defensin 35"
FT /id="PRO_0000006947"
FT DISULFID 31..58
FT /evidence="ECO:0000250"
FT DISULFID 38..52
FT /evidence="ECO:0000250"
FT DISULFID 42..59
FT /evidence="ECO:0000250"
SQ SEQUENCE 63 AA; 7397 MW; 6A04B80ED816EA2E CRC64;
MPQTFFVFCF LFFVFLQLFP GTGEIAVCET CRLGRGKCRR ACIESEKIVG WCKLNFFCCR
ERI
