DFB36_MOUSE
ID DFB36_MOUSE Reviewed; 67 AA.
AC Q8K3U4; A3KGR4; Q3V491;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Beta-defensin 36;
DE Short=BD-36;
DE Short=mBD-36;
DE AltName: Full=Defensin, beta 36;
DE Flags: Precursor;
GN Name=Defb36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Testis;
RA Yashwanth R., Yenugu S., Hamil K.G., French F.S., Hall S.H.;
RT "Male reproductive tract specific rodent beta defensins.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-43.
RC STRAIN=CD-1;
RX PubMed=11854508; DOI=10.1073/pnas.042692699;
RA Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT "Discovery of five conserved beta-defensin gene clusters using a
RT computational search strategy.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012042; AAY59778.1; -; mRNA.
DR EMBL; AY591385; AAT67592.1; -; mRNA.
DR EMBL; AK005872; BAE20419.1; -; mRNA.
DR EMBL; AL845162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF533211; AAM97929.1; -; mRNA.
DR CCDS; CCDS38279.1; -.
DR RefSeq; NP_001032324.1; NM_001037247.4.
DR AlphaFoldDB; Q8K3U4; -.
DR SMR; Q8K3U4; -.
DR STRING; 10090.ENSMUSP00000059665; -.
DR PhosphoSitePlus; Q8K3U4; -.
DR PaxDb; Q8K3U4; -.
DR PRIDE; Q8K3U4; -.
DR ProteomicsDB; 279638; -.
DR DNASU; 266620; -.
DR Ensembl; ENSMUST00000058086; ENSMUSP00000059665; ENSMUSG00000044863.
DR GeneID; 266620; -.
DR KEGG; mmu:266620; -.
DR UCSC; uc008nfu.2; mouse.
DR CTD; 266620; -.
DR MGI; MGI:2385956; Defb36.
DR VEuPathDB; HostDB:ENSMUSG00000044863; -.
DR eggNOG; ENOG502TIGY; Eukaryota.
DR GeneTree; ENSGT00940000162385; -.
DR HOGENOM; CLU_181906_2_0_1; -.
DR InParanoid; Q8K3U4; -.
DR OMA; VYVYCTN; -.
DR OrthoDB; 1606248at2759; -.
DR PhylomeDB; Q8K3U4; -.
DR TreeFam; TF336381; -.
DR Reactome; R-MMU-1461957; Beta defensins.
DR Reactome; R-MMU-1461973; Defensins.
DR BioGRID-ORCS; 266620; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Defb36; mouse.
DR PRO; PR:Q8K3U4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8K3U4; protein.
DR Bgee; ENSMUSG00000044863; Expressed in testis and 11 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PEPTIDE 23..67
FT /note="Beta-defensin 36"
FT /id="PRO_0000006948"
FT DISULFID 25..52
FT /evidence="ECO:0000250"
FT DISULFID 32..46
FT /evidence="ECO:0000250"
FT DISULFID 36..53
FT /evidence="ECO:0000250"
SQ SEQUENCE 67 AA; 7755 MW; 8DAD883652D88AC9 CRC64;
MKLLLLTLAA LLLVSQLTPG DAQKCWNLHG KCRHRCSRKE SVYVYCTNGK MCCVKPKYQP
KPKPWMF
