DFB38_MOUSE
ID DFB38_MOUSE Reviewed; 63 AA.
AC Q7TNV7;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Beta-defensin 38;
DE Short=BD-38;
DE Short=mBD-38;
DE AltName: Full=Defensin, beta 38;
DE Flags: Precursor;
GN Name=Defb38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND SYNTHESIS OF
RP 22-63.
RC STRAIN=BALB/cJ; TISSUE=Epididymis;
RX PubMed=14718547; DOI=10.1074/jbc.m307697200;
RA Zaballos A., Villares R., Albar J.P., Martinez-A C., Marquez G.;
RT "Identification on mouse chromosome 8 of new beta-defensin genes with
RT regionally specific expression in the male reproductive organ.";
RL J. Biol. Chem. 279:12421-12426(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Maxwell A., Dorin J.R.;
RT "Amino acid residues subject to positive selection in murine beta-defensin
RT antimicrobial peptides.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthetic Defb38 kills both Gram-negative (E.coli and
CC P.aeruginosa) and Gram-positive (E.faecium) bacteria.
CC {ECO:0000269|PubMed:14718547}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Only expressed in epididymis (caput, corpus and
CC cauda). {ECO:0000269|PubMed:14718547}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ575424; CAE01397.1; -; mRNA.
DR EMBL; AJ578471; CAE17668.1; -; mRNA.
DR CCDS; CCDS40248.1; -.
DR RefSeq; NP_898857.1; NM_183036.1.
DR AlphaFoldDB; Q7TNV7; -.
DR SMR; Q7TNV7; -.
DR PaxDb; Q7TNV7; -.
DR PRIDE; Q7TNV7; -.
DR ProteomicsDB; 279350; -.
DR DNASU; 360212; -.
DR Ensembl; ENSMUST00000066416; ENSMUSP00000067553; ENSMUSG00000053790.
DR GeneID; 360212; -.
DR KEGG; mmu:360212; -.
DR UCSC; uc009laa.1; mouse.
DR CTD; 360212; -.
DR MGI; MGI:2672972; Defb38.
DR VEuPathDB; HostDB:ENSMUSG00000053790; -.
DR GeneTree; ENSGT01050000245197; -.
DR HOGENOM; CLU_189296_5_1_1; -.
DR InParanoid; Q7TNV7; -.
DR OMA; YFECPWL; -.
DR OrthoDB; 1635261at2759; -.
DR PhylomeDB; Q7TNV7; -.
DR BioGRID-ORCS; 360212; 3 hits in 49 CRISPR screens.
DR PRO; PR:Q7TNV7; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q7TNV7; protein.
DR Bgee; ENSMUSG00000053790; Expressed in testis.
DR ExpressionAtlas; Q7TNV7; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..63
FT /note="Beta-defensin 38"
FT /id="PRO_0000006950"
FT DISULFID 29..58
FT /evidence="ECO:0000250"
FT DISULFID 36..51
FT /evidence="ECO:0000250"
FT DISULFID 41..59
FT /evidence="ECO:0000250"
SQ SEQUENCE 63 AA; 7443 MW; 56C7FCF84834B282 CRC64;
MKISCFLLLI LSLYFFQINQ AIGPDTKKCV QRKNACHYFE CPWLYYSVGT CYKGKGKCCQ
KRY
