DFB39_MOUSE
ID DFB39_MOUSE Reviewed; 74 AA.
AC Q70KL3; Q7TNV6;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Beta-defensin 39;
DE Short=BD-39;
DE Short=mBD-39;
DE AltName: Full=Defensin, beta 39;
DE Flags: Precursor;
GN Name=Defb39;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Epididymis;
RX PubMed=14718547; DOI=10.1074/jbc.m307697200;
RA Zaballos A., Villares R., Albar J.P., Martinez-A C., Marquez G.;
RT "Identification on mouse chromosome 8 of new beta-defensin genes with
RT regionally specific expression in the male reproductive organ.";
RL J. Biol. Chem. 279:12421-12426(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Maxwell A., Dorin J.R.;
RT "Amino acid residues subject to positive selection in murine b-defensin
RT antimicrobial peptides.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Only expressed in epididymis (caput, corpus and
CC cauda). {ECO:0000269|PubMed:14718547}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ575425; CAE01398.1; -; mRNA.
DR EMBL; AJ578472; CAE17669.1; -; mRNA.
DR CCDS; CCDS22130.1; -.
DR RefSeq; NP_898859.2; NM_183038.2.
DR AlphaFoldDB; Q70KL3; -.
DR SMR; Q70KL3; -.
DR STRING; 10090.ENSMUSP00000074947; -.
DR PaxDb; Q70KL3; -.
DR PRIDE; Q70KL3; -.
DR DNASU; 360214; -.
DR GeneID; 360214; -.
DR KEGG; mmu:360214; -.
DR UCSC; uc009lab.1; mouse.
DR CTD; 360214; -.
DR MGI; MGI:2672974; Defb39.
DR InParanoid; Q70KL3; -.
DR OrthoDB; 1635261at2759; -.
DR PhylomeDB; Q70KL3; -.
DR BioGRID-ORCS; 360214; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Defb39; mouse.
DR PRO; PR:Q70KL3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q70KL3; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..74
FT /note="Beta-defensin 39"
FT /id="PRO_0000006951"
FT DISULFID 29..58
FT /evidence="ECO:0000250"
FT DISULFID 36..51
FT /evidence="ECO:0000250"
FT DISULFID 41..59
FT /evidence="ECO:0000250"
FT CONFLICT 54
FT /note="K -> R (in Ref. 2; CAE17669)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 74 AA; 8552 MW; 30E123CE7363C1A7 CRC64;
MKISYFLLLI LSLGSSQINP VSGDDSIQCF QKNNTCHTNQ CPYFQDEIGT CYDKRGKCCQ
KRLLHIRVPR KKKV
