ID   DFB39_RAT               Reviewed;          73 AA.
AC   Q32ZF7;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Beta-defensin 39;
DE            Short=BD-39;
DE   AltName: Full=Defensin, beta 39;
DE   Flags: Precursor;
GN   Name=Defb39;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621366; AAT51905.1; -; mRNA.
DR   RefSeq; NP_001032611.1; NM_001037522.1.
DR   AlphaFoldDB; Q32ZF7; -.
DR   SMR; Q32ZF7; -.
DR   STRING; 10116.ENSRNOP00000039757; -.
DR   PaxDb; Q32ZF7; -.
DR   Ensembl; ENSRNOT00000040406; ENSRNOP00000039757; ENSRNOG00000034275.
DR   GeneID; 641646; -.
DR   KEGG; rno:641646; -.
DR   UCSC; RGD:1563816; rat.
DR   CTD; 360214; -.
DR   RGD; 1563816; Defb39.
DR   GeneTree; ENSGT01050000245197; -.
DR   HOGENOM; CLU_189296_5_1_1; -.
DR   InParanoid; Q32ZF7; -.
DR   OMA; QKNNTCH; -.
DR   OrthoDB; 1635261at2759; -.
DR   PhylomeDB; Q32ZF7; -.
DR   PRO; PR:Q32ZF7; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000034275; Expressed in stomach and 2 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..73
FT                   /note="Beta-defensin 39"
FT                   /id="PRO_0000352715"
FT   DISULFID        29..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..59
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   73 AA;  8308 MW;  13C5EA174B955DDA CRC64;
     MKISCFLLLV LSLSCFQINS VSGIDSVKCF QKNNTCHTIR CPYFQDEVGT CYEGRGKCCQ
     KRLLSIRVPK KKV