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DFB40_MOUSE
ID   DFB40_MOUSE             Reviewed;          73 AA.
AC   Q70KL2; Q7TNV5;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Beta-defensin 40;
DE            Short=BD-40;
DE            Short=mBD-40;
DE   AltName: Full=Defensin, beta 40;
DE   Flags: Precursor;
GN   Name=Defb40;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=BALB/cJ; TISSUE=Epididymis;
RX   PubMed=14718547; DOI=10.1074/jbc.m307697200;
RA   Zaballos A., Villares R., Albar J.P., Martinez-A C., Marquez G.;
RT   "Identification on mouse chromosome 8 of new beta-defensin genes with
RT   regionally specific expression in the male reproductive organ.";
RL   J. Biol. Chem. 279:12421-12426(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Maxwell A., Dorin J.R.;
RT   "Likelihood based analysis of the murine beta defensin gene family reveals
RT   the amino acids subject to positive selection.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Only expressed in epididymis (corpus, cauda and
CC       caput). {ECO:0000269|PubMed:14718547}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AJ575426; CAE01399.1; -; mRNA.
DR   EMBL; AJ578473; CAE17670.1; -; mRNA.
DR   CCDS; CCDS40246.1; -.
DR   RefSeq; NP_898860.3; NM_183039.3.
DR   AlphaFoldDB; Q70KL2; -.
DR   SMR; Q70KL2; -.
DR   PaxDb; Q70KL2; -.
DR   PRIDE; Q70KL2; -.
DR   DNASU; 360217; -.
DR   GeneID; 360217; -.
DR   KEGG; mmu:360217; -.
DR   UCSC; uc009kzy.1; mouse.
DR   CTD; 360217; -.
DR   MGI; MGI:2672976; Defb40.
DR   InParanoid; Q70KL2; -.
DR   OrthoDB; 1635261at2759; -.
DR   PhylomeDB; Q70KL2; -.
DR   BioGRID-ORCS; 360217; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q70KL2; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q70KL2; protein.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..73
FT                   /note="Beta-defensin 40"
FT                   /id="PRO_0000006952"
FT   DISULFID        29..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..59
FT                   /evidence="ECO:0000250"
FT   CONFLICT        68
FT                   /note="S -> N (in Ref. 2; CAE17670)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   73 AA;  8616 MW;  D4219CE69ADB0A3E CRC64;
     MKISCFLLMI FFLSCFQINP VAVLDTIKCL QGNNNCHIQK CPWFLLQVST CYKGKGRCCQ
     KRRWFARSHV YHV
 
 
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