DFB41_MOUSE
ID DFB41_MOUSE Reviewed; 65 AA.
AC Q30KP6; Q4FZ55; Q8C1G4;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Beta-defensin 41 {ECO:0000312|MGI:MGI:1924923};
DE Short=BD-41 {ECO:0000305};
DE Short=mBD-41;
DE AltName: Full=Defensin, beta 41 {ECO:0000312|MGI:MGI:1924923};
DE Flags: Precursor;
GN Name=Defb41 {ECO:0000312|MGI:MGI:1924923};
GN Synonyms=Defb16 {ECO:0000303|PubMed:16033865},
GN Defb17 {ECO:0000303|PubMed:16033865},
GN Gm15386 {ECO:0000312|MGI:MGI:1924923};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16023745; DOI=10.1016/j.bbaexp.2005.05.010;
RA Jalkanen J., Huhtaniemi I., Poutanen M.;
RT "Discovery and characterization of new epididymis-specific beta-defensins
RT in mice.";
RL Biochim. Biophys. Acta 1730:22-30(2005).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250|UniProtKB:P81534}.
CC -!- FUNCTION: Isoform 2 may play a role in the antimicrobial protection of
CC sperm and urogenital tract epithelia. {ECO:0000269|PubMed:16023745}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q30KP6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q30KP6-2; Sequence=VSP_057922;
CC -!- TISSUE SPECIFICITY: Isoform 2 is epididymis-specific and expressed
CC mainly in the proximal caput. {ECO:0000269|PubMed:16023745}.
CC -!- INDUCTION: By androgens. {ECO:0000269|PubMed:16023745}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012027; AAY59763.1; -; mRNA.
DR EMBL; DQ012028; AAY59764.1; -; mRNA.
DR EMBL; AK020304; BAC25620.1; -; mRNA.
DR EMBL; BK005412; DAA05561.1; -; mRNA.
DR RefSeq; NP_001035116.1; NM_001040027.2. [Q30KP6-1]
DR RefSeq; NP_898947.1; NM_183124.3. [Q30KP6-2]
DR AlphaFoldDB; Q30KP6; -.
DR SMR; Q30KP6; -.
DR STRING; 10090.ENSMUSP00000095426; -.
DR iPTMnet; Q30KP6; -.
DR PaxDb; Q30KP6; -.
DR PRIDE; Q30KP6; -.
DR ProteomicsDB; 279639; -. [Q30KP6-1]
DR Antibodypedia; 57764; 12 antibodies from 4 providers.
DR DNASU; 77673; -.
DR Ensembl; ENSMUST00000088463; ENSMUSP00000085811; ENSMUSG00000067773. [Q30KP6-2]
DR Ensembl; ENSMUST00000097817; ENSMUSP00000095426; ENSMUSG00000067773. [Q30KP6-1]
DR GeneID; 77673; -.
DR KEGG; mmu:77673; -.
DR UCSC; uc007ako.1; mouse. [Q30KP6-1]
DR CTD; 77673; -.
DR MGI; MGI:1924923; Defb41.
DR VEuPathDB; HostDB:ENSMUSG00000067773; -.
DR eggNOG; ENOG502TGN0; Eukaryota.
DR GeneTree; ENSGT00390000006761; -.
DR HOGENOM; CLU_187020_0_0_1; -.
DR InParanoid; Q30KP6; -.
DR OMA; EGNGRCK; -.
DR OrthoDB; 1610592at2759; -.
DR PhylomeDB; Q30KP6; -.
DR BioGRID-ORCS; 77673; 2 hits in 38 CRISPR screens.
DR ChiTaRS; Defb41; mouse.
DR PRO; PR:Q30KP6; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q30KP6; protein.
DR Bgee; ENSMUSG00000067773; Expressed in spermatid and 16 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..65
FT /note="Beta-defensin 41"
FT /id="PRO_0000352701"
FT DISULFID 35..63
FT /evidence="ECO:0000250|UniProtKB:P81534"
FT DISULFID 42..56
FT /evidence="ECO:0000250|UniProtKB:P81534"
FT DISULFID 46..64
FT /evidence="ECO:0000250|UniProtKB:P81534"
FT VAR_SEQ 20..65
FT /note="KKSYPEYGSLDLRKECKMRRGHCKLQCSEKELRISFCIRPGTHCCM -> RS
FT HIDIKNGIERCEKVRGMCKTVCDIDEYDYGYCIRWRNQCCI (in isoform 2)"
FT /id="VSP_057922"
SQ SEQUENCE 65 AA; 7663 MW; 693BCECE4F4C57B2 CRC64;
MKFHLFFFIL LFGATILTAK KSYPEYGSLD LRKECKMRRG HCKLQCSEKE LRISFCIRPG
THCCM
