DFB42_MOUSE
ID DFB42_MOUSE Reviewed; 75 AA.
AC Q8BVB5; Q4FZ54;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Beta-defensin 42 {ECO:0000312|MGI:MGI:3033850};
DE Short=BD-42 {ECO:0000305};
DE Short=mBD-42 {ECO:0000305};
DE AltName: Full=Defensin, beta 42 {ECO:0000312|MGI:MGI:3033850};
DE Flags: Precursor;
GN Name=Defb42 {ECO:0000312|MGI:MGI:3033850};
GN Synonyms=Defb44 {ECO:0000303|PubMed:16033865};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAY59782.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2] {ECO:0000312|EMBL:BAC37510.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000312|EMBL:AAI46023.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6] {ECO:0000312|EMBL:DAA05562.1}
RP IDENTIFICATION, FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:DAA05562.1};
RC TISSUE=Epididymis {ECO:0000312|EMBL:DAA05562.1};
RX PubMed=16023745; DOI=10.1016/j.bbaexp.2005.05.010;
RA Jalkanen J., Huhtaniemi I., Poutanen M.;
RT "Discovery and characterization of new epididymis-specific beta-defensins
RT in mice.";
RL Biochim. Biophys. Acta 1730:22-30(2005).
CC -!- FUNCTION: Has bactericidal activity (By similarity). May play a role in
CC the antimicrobial protection of sperm and urogenital tract epithelia
CC (PubMed:16023745). {ECO:0000250|UniProtKB:P81534,
CC ECO:0000269|PubMed:16023745}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}.
CC -!- TISSUE SPECIFICITY: Epididymis-specific, with highest levels in the
CC initial segment and distal caput. {ECO:0000269|PubMed:16023745}.
CC -!- INDUCTION: By androgens. {ECO:0000269|PubMed:16023745}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012046; AAY59782.1; -; mRNA.
DR EMBL; AK079042; BAC37510.1; -; mRNA.
DR EMBL; AC090659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466535; EDL36074.1; -; Genomic_DNA.
DR EMBL; CH466535; EDL36075.1; -; Genomic_DNA.
DR EMBL; BC146022; AAI46023.1; -; mRNA.
DR EMBL; BC146024; AAI46025.1; -; mRNA.
DR EMBL; BK005413; DAA05562.1; -; mRNA.
DR CCDS; CCDS36948.1; -.
DR RefSeq; NP_001030082.1; NM_001034910.3.
DR AlphaFoldDB; Q8BVB5; -.
DR STRING; 10090.ENSMUSP00000070629; -.
DR PaxDb; Q8BVB5; -.
DR PRIDE; Q8BVB5; -.
DR ProteomicsDB; 279524; -.
DR Antibodypedia; 67428; 9 antibodies from 6 providers.
DR Ensembl; ENSMUST00000067990; ENSMUSP00000070629; ENSMUSG00000054763.
DR Ensembl; ENSMUST00000111203; ENSMUSP00000106834; ENSMUSG00000054763.
DR GeneID; 619548; -.
DR KEGG; mmu:619548; -.
DR UCSC; uc007uhf.2; mouse.
DR CTD; 619548; -.
DR MGI; MGI:3033850; Defb42.
DR VEuPathDB; HostDB:ENSMUSG00000054763; -.
DR eggNOG; ENOG502R7G8; Eukaryota.
DR GeneTree; ENSGT00390000001862; -.
DR HOGENOM; CLU_198474_0_0_1; -.
DR InParanoid; Q8BVB5; -.
DR OMA; WVAFCHN; -.
DR OrthoDB; 1577169at2759; -.
DR PhylomeDB; Q8BVB5; -.
DR TreeFam; TF343350; -.
DR Reactome; R-MMU-1461957; Beta defensins.
DR Reactome; R-MMU-1461973; Defensins.
DR BioGRID-ORCS; 619548; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8BVB5; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BVB5; protein.
DR Bgee; ENSMUSG00000054763; Expressed in seminal vesicle and 35 other tissues.
DR ExpressionAtlas; Q8BVB5; baseline and differential.
DR Genevisible; Q8BVB5; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001530; F:lipopolysaccharide binding; ISO:MGI.
DR GO; GO:0140367; P:antibacterial innate immune response; ISO:MGI.
DR GO; GO:0061760; P:antifungal innate immune response; ISO:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR InterPro; IPR035307; DEFB136/42.
DR PANTHER; PTHR39413; PTHR39413; 1.
DR Pfam; PF17333; DEFB136; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..75
FT /note="Beta-defensin 42"
FT /evidence="ECO:0000305"
FT /id="PRO_0000434510"
FT DISULFID 33..60
FT /evidence="ECO:0000250|UniProtKB:P81534"
FT DISULFID 40..54
FT /evidence="ECO:0000250|UniProtKB:P81534"
FT DISULFID 44..61
FT /evidence="ECO:0000250|UniProtKB:P81534"
SQ SEQUENCE 75 AA; 8287 MW; 70343072115C0647 CRC64;
MNLRLSCLLF ILVTSLPAGR CSIGNKGISF ETCTAIEGLC FFGCKLGWVW IAYCNNIMSC
CRKDTDFVLP QTKGI
