DFB43_MOUSE
ID DFB43_MOUSE Reviewed; 69 AA.
AC Q30KM9;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Beta-defensin 43;
DE Short=BD-43;
DE Short=mBD-43;
DE AltName: Full=Defensin, beta 43;
DE Flags: Precursor;
GN Name=Defb43;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012045; AAY59781.1; -; mRNA.
DR EMBL; BC132224; AAI32225.1; -; mRNA.
DR EMBL; BC132560; AAI32561.1; -; mRNA.
DR CCDS; CCDS36946.1; -.
DR RefSeq; NP_001034210.1; NM_001039121.1.
DR AlphaFoldDB; Q30KM9; -.
DR SMR; Q30KM9; -.
DR STRING; 10090.ENSMUSP00000098060; -.
DR PaxDb; Q30KM9; -.
DR PRIDE; Q30KM9; -.
DR ProteomicsDB; 279408; -.
DR Ensembl; ENSMUST00000100491; ENSMUSP00000098060; ENSMUSG00000075572.
DR GeneID; 654458; -.
DR KEGG; mmu:654458; -.
DR UCSC; uc007uhc.1; mouse.
DR CTD; 654458; -.
DR MGI; MGI:3647180; Defb43.
DR VEuPathDB; HostDB:ENSMUSG00000075572; -.
DR eggNOG; ENOG502TEDN; Eukaryota.
DR GeneTree; ENSGT00390000001538; -.
DR HOGENOM; CLU_203372_0_0_1; -.
DR InParanoid; Q30KM9; -.
DR OMA; EYAVRYC; -.
DR OrthoDB; 1638187at2759; -.
DR PhylomeDB; Q30KM9; -.
DR TreeFam; TF341399; -.
DR Reactome; R-MMU-1461957; Beta defensins.
DR Reactome; R-MMU-1461973; Defensins.
DR BioGRID-ORCS; 654458; 2 hits in 69 CRISPR screens.
DR ChiTaRS; Defb43; mouse.
DR PRO; PR:Q30KM9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q30KM9; protein.
DR Bgee; ENSMUSG00000075572; Expressed in testis and 4 other tissues.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..69
FT /note="Beta-defensin 43"
FT /id="PRO_0000352716"
FT DISULFID 29..56
FT /evidence="ECO:0000250"
FT DISULFID 35..49
FT /evidence="ECO:0000250"
SQ SEQUENCE 69 AA; 8252 MW; 13FDD9085D9CC270 CRC64;
MRVLFSILGV LTLLSIVPLA RSFLENQDCS KHRHCRMKCK ANEYAVRYCE DWTICCRVKK
KESKKKKMW
