DFB50_MOUSE
ID DFB50_MOUSE Reviewed; 73 AA.
AC Q6TU36; Q30KM7;
DT 02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Beta-defensin 50;
DE Short=BD-50;
DE Short=mBD-50;
DE AltName: Full=Defensin, beta 37;
DE AltName: Full=Defensin, beta 50;
DE AltName: Full=Prostate beta-defensin 1;
DE Flags: Precursor;
GN Name=Defb50; Synonyms=Defb37, Pbd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Prostate;
RX PubMed=14659016; DOI=10.1186/gb-2003-4-12-r79;
RA Abbott D.E., Pritchard C., Clegg N.J., Ferguson C., Dumpit R., Sikes R.A.,
RA Nelson P.S.;
RT "Expressed sequence tag profiling identifies developmental and anatomic
RT partitioning of gene expression in the mouse prostate.";
RL Genome Biol. 4:R79.1-R79.15(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Patil A.A., Zhang G.;
RT "Genome-wide analysis of rat beta-defensins: evidence for the existence of
RT four syntenic defensin gene clusters in mammals.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in prostate. Not expressed in
CC uterus, epididymis, ovary, testis, spleen, submaxillary gland, thymus,
CC thyroid, pancreas, smooth muscle, skeletal muscle, heart, kidney, lung,
CC liver, eye and brain. {ECO:0000269|PubMed:14659016}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY387658; AAR25850.1; -; mRNA.
DR EMBL; DQ012050; AAY59783.1; -; mRNA.
DR EMBL; AY621336; AAT51875.1; -; mRNA.
DR EMBL; AL590630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS40283.1; -.
DR RefSeq; NP_951022.1; NM_199067.1.
DR AlphaFoldDB; Q6TU36; -.
DR STRING; 10090.ENSMUSP00000077918; -.
DR PaxDb; Q6TU36; -.
DR PRIDE; Q6TU36; -.
DR ProteomicsDB; 279641; -.
DR DNASU; 387334; -.
DR Ensembl; ENSMUST00000078879; ENSMUSP00000077918; ENSMUSG00000058568.
DR GeneID; 387334; -.
DR KEGG; mmu:387334; -.
DR UCSC; uc009lbz.1; mouse.
DR CTD; 387334; -.
DR MGI; MGI:3055870; Defb50.
DR VEuPathDB; HostDB:ENSMUSG00000058568; -.
DR GeneTree; ENSGT00520000061209; -.
DR HOGENOM; CLU_2704193_0_0_1; -.
DR InParanoid; Q6TU36; -.
DR OMA; KSVCCMV; -.
DR OrthoDB; 1630145at2759; -.
DR BioGRID-ORCS; 387334; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Defb50; mouse.
DR PRO; PR:Q6TU36; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q6TU36; protein.
DR Bgee; ENSMUSG00000058568; Expressed in primary oocyte and 9 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR035193; Defb50.
DR Pfam; PF17546; Defb50; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..73
FT /note="Beta-defensin 50"
FT /id="PRO_0000006954"
FT DISULFID 34..63
FT /evidence="ECO:0000250"
FT DISULFID 46..64
FT /evidence="ECO:0000250"
SQ SEQUENCE 73 AA; 8058 MW; DC0B3B8A3A917C69 CRC64;
MKTLCFLLLT SGLLYLMVKG VGSHPGTFHV RIKCMPKMTA VFGDNCSFYS SMGDLCNNTK
SVCCMVPVRM DNI
