ID   DFB50_RAT               Reviewed;          73 AA.
AC   Q30KJ2;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Beta-defensin 50;
DE            Short=BD-50;
DE   AltName: Full=Defensin, beta 50;
DE   Flags: Precursor;
GN   Name=Defb50;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012090; AAY59818.1; -; mRNA.
DR   EMBL; BC168240; AAI68240.1; -; mRNA.
DR   RefSeq; NP_001032602.1; NM_001037513.1.
DR   AlphaFoldDB; Q30KJ2; -.
DR   STRING; 10116.ENSRNOP00000041922; -.
DR   PaxDb; Q30KJ2; -.
DR   Ensembl; ENSRNOT00000046156; ENSRNOP00000041922; ENSRNOG00000033972.
DR   GeneID; 641639; -.
DR   KEGG; rno:641639; -.
DR   UCSC; RGD:1563282; rat.
DR   CTD; 387334; -.
DR   RGD; 1563282; Defb50.
DR   GeneTree; ENSGT00520000061209; -.
DR   HOGENOM; CLU_2704193_0_0_1; -.
DR   InParanoid; Q30KJ2; -.
DR   OMA; KSVCCMV; -.
DR   OrthoDB; 1630145at2759; -.
DR   PRO; PR:Q30KJ2; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000033972; Expressed in thymus and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR035193; Defb50.
DR   Pfam; PF17546; Defb50; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..73
FT                   /note="Beta-defensin 50"
FT                   /id="PRO_0000352718"
FT   DISULFID        34..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..64
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   73 AA;  7900 MW;  7861181462DD6613 CRC64;
     MKTLHLLLLI SGLLSVFVKG VGSHPGTVHV RFKCIPKIAA VFGDNCPFYG NVDGLCNDKK
     SVCCMVPVRL DNI