ID   DFBC7_BOVIN             Reviewed;          53 AA.
AC   O18815;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Beta-defensin C7;
DE   AltName: Full=BBD(C7);
DE   Flags: Precursor; Fragment;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=9488394; DOI=10.1128/iai.66.3.1045-1056.1998;
RA   Tarver A.P., Clark D.P., Diamond G., Russell J.P., Erdjument-Bromage H.,
RA   Tempst P., Cohen K.S., Jones D.E., Sweeney R.W., Wines M., Hwang S.,
RA   Bevins C.L.;
RT   "Enteric beta-defensin: molecular cloning and characterization of a gene
RT   with inducible intestinal epithelial cell expression associated with
RT   Cryptosporidium parvum infection.";
RL   Infect. Immun. 66:1045-1056(1998).
CC   -!- FUNCTION: Has bactericidal activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF016395; AAC48802.1; -; mRNA.
DR   AlphaFoldDB; O18815; -.
DR   SMR; O18815; -.
DR   PRIDE; O18815; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          <1..?
FT                   /evidence="ECO:0000255"
FT   PROPEP          ?..15
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000006886"
FT   PEPTIDE         16..53
FT                   /note="Beta-defensin C7"
FT                   /id="PRO_0000006887"
FT   DISULFID        20..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        27..42
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..50
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   53 AA;  5650 MW;  34659DF3A0489F4A CRC64;
     LALLFLVLSA GSGISGPLSC RRKGGICILI RCPGPMRQIG TCFGRPVKCC RSW