DFC_ARATH
ID DFC_ARATH Reviewed; 164 AA.
AC Q9LX15;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein DOWNSTREAM OF FLC;
DE Short=AtDFC;
DE AltName: Full=Pollen allergen-like protein;
DE Flags: Precursor;
GN Name=DFC; OrderedLocusNames=At5g10130; ORFNames=T31P16.120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Cheuk R., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND INDUCTION BY VERNALIZATION.
RX PubMed=15186749; DOI=10.1016/j.cub.2004.04.045;
RA Finnegan E.J., Sheldon C.C., Jardinaud F., Peacock W.J., Dennis E.S.;
RT "A cluster of Arabidopsis genes with a coordinate response to an
RT environmental stimulus.";
RL Curr. Biol. 14:911-916(2004).
RN [5]
RP FUNCTION.
RX PubMed=18156133; DOI=10.1093/pcp/pcm176;
RA Andersson C.R., Helliwell C.A., Bagnall D.J., Hughes T.P., Finnegan E.J.,
RA Peacock W.J., Dennis E.S.;
RT "The FLX gene of Arabidopsis is required for FRI-dependent activation of
RT FLC expression.";
RL Plant Cell Physiol. 49:191-200(2008).
CC -!- FUNCTION: Part of a three-gene cluster containing FLC, UFC and DFC,
CC which is coordinately regulated in response to vernalization. Not
CC regulated by FLX. {ECO:0000269|PubMed:15186749,
CC ECO:0000269|PubMed:18156133}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- INDUCTION: Epigenetically down-regulated by vernalization.
CC {ECO:0000269|PubMed:15186749}.
CC -!- SIMILARITY: Belongs to the Ole e I family. {ECO:0000305}.
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DR EMBL; AL356332; CAB92054.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91497.1; -; Genomic_DNA.
DR EMBL; BT010846; AAR24213.1; -; mRNA.
DR EMBL; BT012613; AAT06432.1; -; mRNA.
DR PIR; T50017; T50017.
DR RefSeq; NP_196575.1; NM_121051.3.
DR AlphaFoldDB; Q9LX15; -.
DR SMR; Q9LX15; -.
DR STRING; 3702.AT5G10130.1; -.
DR PaxDb; Q9LX15; -.
DR PRIDE; Q9LX15; -.
DR ProteomicsDB; 224208; -.
DR EnsemblPlants; AT5G10130.1; AT5G10130.1; AT5G10130.
DR GeneID; 830877; -.
DR Gramene; AT5G10130.1; AT5G10130.1; AT5G10130.
DR KEGG; ath:AT5G10130; -.
DR Araport; AT5G10130; -.
DR TAIR; locus:2184103; AT5G10130.
DR eggNOG; ENOG502S31U; Eukaryota.
DR HOGENOM; CLU_094008_2_0_1; -.
DR InParanoid; Q9LX15; -.
DR OMA; EDQICEC; -.
DR OrthoDB; 1405935at2759; -.
DR PhylomeDB; Q9LX15; -.
DR PRO; PR:Q9LX15; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LX15; baseline and differential.
DR Genevisible; Q9LX15; AT.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR InterPro; IPR006040; Allergen_Ole_e_I_CS.
DR InterPro; IPR006041; Pollen_Ole_e1_allergen.
DR PANTHER; PTHR31614; PTHR31614; 1.
DR PROSITE; PS00925; OLEEI; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..164
FT /note="Protein DOWNSTREAM OF FLC"
FT /id="PRO_0000423723"
FT DISULFID 36..107
FT /evidence="ECO:0000250"
FT DISULFID 39..148
FT /evidence="ECO:0000250"
FT DISULFID 60..95
FT /evidence="ECO:0000250"
SQ SEQUENCE 164 AA; 17819 MW; C58FC030B554AEAD CRC64;
MAKSFVPLIA VLCVLVLPLA AMAVGTPFHI EGSVYCDTCR FGFETIATQY IRGARVRIVC
KDRVTLKSEL VGVAVTGPDG KYKVAVRGDR QDQQCLAELV HSPLSRCQEA DPGRSTATVI
LTRSNGAAST RHYANAMGFF RDEPLRGCAA LRKRYLADGD NRAI
