ID   DFI8A_XENLA             Reviewed;         443 AA.
AC   Q6DDJ3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Differentially expressed in FDCP 8 homolog A;
DE            Short=DEF-8-A;
GN   Name=def8-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates lysosome peripheral distribution and
CC       ruffled border formation in osteoclasts. Involved in bone resorption.
CC       {ECO:0000250|UniProtKB:Q99J78}.
CC   -!- SIMILARITY: Belongs to the DEF8 family. {ECO:0000305}.
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DR   EMBL; BC077567; AAH77567.1; -; mRNA.
DR   RefSeq; NP_001086859.1; NM_001093390.1.
DR   AlphaFoldDB; Q6DDJ3; -.
DR   SMR; Q6DDJ3; -.
DR   DNASU; 446694; -.
DR   GeneID; 446694; -.
DR   KEGG; xla:446694; -.
DR   CTD; 446694; -.
DR   Xenbase; XB-GENE-17345812; def8.L.
DR   OMA; IEPRLCD; -.
DR   OrthoDB; 177737at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 446694; Expressed in spleen and 19 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0045780; P:positive regulation of bone resorption; ISS:UniProtKB.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR036280; Multihaem_cyt_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR025258; Zf-RING_9.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF13901; zf-RING_9; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM01175; DUF4206; 1.
DR   SUPFAM; SSF48695; SSF48695; 1.
DR   SUPFAM; SSF57889; SSF57889; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..443
FT                   /note="Differentially expressed in FDCP 8 homolog A"
FT                   /id="PRO_0000321916"
FT   ZN_FING         134..185
FT                   /note="Phorbol-ester/DAG-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT   ZN_FING         364..424
FT                   /note="Phorbol-ester/DAG-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  51323 MW;  7486DA5142EC474A CRC64;
     MEYDDKLVRF RQGHLNPFDK QGGAERHPAD SEAQPPKDSS TISPHSIPEY HCPDRVMDLG
     VSEDHFSRPV GLFLASDIQQ LRQAIEECKQ EILELPENSD RQKDAVVRLI HLRLKLQELN
     DPLEDEPNLR ILLEHRFYKE KSKSVKHVCD KCSTFIWGLI QTWYTCTGCS YSCHSKCLNL
     ITKPCVRSKV SHQAEYELSI CPEAGLDSQD YRCAECRTPI SLRAVPSEAR QCDYTGQYYC
     ISCHWNDLAV IPARAIHNWD FEPRKVSRCS MRYLALMLGR PVLKLREINP LLFNYVEELV
     EIRKLRQDIL LMKPYFITCK EAMEARLLLQ LQDRQHFVEN DDMYSLQDLL DISSGRLGCT
     LTEIHTTFAK HIKLDCERCQ AKGFVCELCK EGDILFPFDS HTSVCQDCAA VFHRDCYYDN
     STSCPRCMRL SLRKQTQNPE AEP