ID   DFI8B_XENLA             Reviewed;         443 AA.
AC   Q7T0P6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Differentially expressed in FDCP 8 homolog B;
DE            Short=DEF-8-B;
GN   Name=def8-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates lysosome peripheral distribution and
CC       ruffled border formation in osteoclasts. Involved in bone resorption.
CC       {ECO:0000250|UniProtKB:Q99J78}.
CC   -!- SIMILARITY: Belongs to the DEF8 family. {ECO:0000305}.
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DR   EMBL; BC056097; AAH56097.1; -; mRNA.
DR   RefSeq; NP_001080885.1; NM_001087416.1.
DR   AlphaFoldDB; Q7T0P6; -.
DR   SMR; Q7T0P6; -.
DR   PRIDE; Q7T0P6; -.
DR   DNASU; 380579; -.
DR   GeneID; 380579; -.
DR   KEGG; xla:380579; -.
DR   CTD; 380579; -.
DR   Xenbase; XB-GENE-967887; def8.S.
DR   OrthoDB; 177737at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 380579; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0045780; P:positive regulation of bone resorption; ISS:UniProtKB.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR036280; Multihaem_cyt_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR025258; Zf-RING_9.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF13901; zf-RING_9; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM01175; DUF4206; 1.
DR   SUPFAM; SSF48695; SSF48695; 1.
DR   SUPFAM; SSF57889; SSF57889; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..443
FT                   /note="Differentially expressed in FDCP 8 homolog B"
FT                   /id="PRO_0000321917"
FT   ZN_FING         134..185
FT                   /note="Phorbol-ester/DAG-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT   ZN_FING         364..424
FT                   /note="Phorbol-ester/DAG-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT   REGION          14..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  51354 MW;  1961E97E6606977F CRC64;
     MEYDDKLVRF RQGHLNPFDK KGGAERHPAD SETQPCKDSS TSSPLSVPEY NYPDRVMDLG
     VSEDHFSRPV GLFLASDVQQ LRQAIEECKQ EILELPENSD RQKDAVVRLI HLRLKLQELN
     DPLEDEPNLR VLLEHRFYKE KSKSVKHLCD KCSTFIWGLI QTWYTCTGCS YSCHSKCLNL
     ITKPCVRSKV SHQAEYELSI CPEAGLDSQD YRCAECRTPI SLRAVPSEAR QCDYTGQYYC
     ISCHWNDLAV IPARAIHNWD FEPCKVSRYS MRYLALMLGR PVLKLREINP LLFNYVEELV
     EIRKLRQDIL LMKPYFITCK EAMEDRLLLQ LQDRQHFVEN DDMYSLQDLL DISSGRLGCS
     LTEIHTTFAK HIKLDCERCQ AKGFMCELCK EGDILFPFDS HTSVCQDCAA VFHRDCYYEN
     STSCPRCMRL NLRKQVQNPG AEP