ID   DFP11_HYPCU             Reviewed;         165 AA.
AC   O96382;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Putative defense protein Hdd11;
DE   AltName: Full=Hyphantria differentially displayed gene 11;
DE   Flags: Precursor;
OS   Hyphantria cunea (Fall webworm moth) (Phalaena cunea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Erebidae; Arctiinae; Hyphantria.
OX   NCBI_TaxID=39466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RX   PubMed=9818384; DOI=10.1016/s0965-1748(98)00077-0;
RA   Shin S.W., Park S.-S., Park D.-S., Kim M.G., Kim S.C., Brey P.T.,
RA   Park H.-Y.;
RT   "Isolation and characterization of immune-related genes from the fall
RT   webworm, Hyphantria cunea, using PCR-based differential display and
RT   subtractive cloning.";
RL   Insect Biochem. Mol. Biol. 28:827-837(1998).
CC   -!- FUNCTION: As this protein is expressed upon bacterial infection, it may
CC       have antimicrobial activity. {ECO:0000269|PubMed:9818384}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: In larvae, by bacteria (E.coli and M.luteus).
CC       {ECO:0000269|PubMed:9818384}.
CC   -!- SIMILARITY: Belongs to the insect defense protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF034999; AAD09280.1; -; mRNA.
DR   AlphaFoldDB; O96382; -.
DR   SMR; O96382; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0042832; P:defense response to protozoan; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd08544; Reeler; 1.
DR   Gene3D; 2.60.40.4060; -; 1.
DR   InterPro; IPR002861; Reeler_dom.
DR   InterPro; IPR042307; Reeler_sf.
DR   Pfam; PF02014; Reeler; 1.
DR   PROSITE; PS51019; REELIN; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Immunity; Innate immunity;
KW   Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..165
FT                   /note="Putative defense protein Hdd11"
FT                   /id="PRO_0000372771"
FT   DOMAIN          18..165
FT                   /note="Reelin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00363"
FT   DISULFID        27..104
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   165 AA;  17756 MW;  7A5D05FA3A86F887 CRC64;
     MWATYVFIAV SLACANGYSS GAPESVCQDM VPKHPVPPQS TPPPYTITTS TKTVKAGTPM
     EVVITGKKPT DKMRGLLLQA REGTKIVGKF TLAPNDPFAQ LLNCGEPGNA ITHKKHDEKN
     DKQTVAFTWT PPKDFVGEIK FRATIALNGA VFWVGVESGP VKVIS