ID   DFP11_SAMRI             Reviewed;         167 AA.
AC   Q765V4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Putative defense protein Hdd11-like;
DE   Flags: Precursor;
OS   Samia ricini (Indian eri silkmoth) (Samia cynthia ricini).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Saturniinae; Attacini; Samia.
OX   NCBI_TaxID=63990;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Fat body;
RX   PubMed=15012905; DOI=10.1016/j.cca.2003.10.007;
RA   Bao Y., Mega K., Yamano Y., Morishima I.;
RT   "cDNA cloning and expression of bacteria-induced Hdd11 gene from eri-
RT   silkworm, Samia cynthia ricini.";
RL   Comp. Biochem. Physiol. 136C:337-342(2003).
CC   -!- FUNCTION: May have antimicrobial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: In larvae, high expression in the fat body and low
CC       expression in midgut, hemocytes and malpighian tubules. No expression
CC       in silkgland. {ECO:0000269|PubMed:15012905}.
CC   -!- INDUCTION: In larvae, by bacterial cells or peptidoglycans.
CC       {ECO:0000269|PubMed:15012905}.
CC   -!- SIMILARITY: Belongs to the insect defense protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB115556; BAD05929.1; -; mRNA.
DR   AlphaFoldDB; Q765V4; -.
DR   SMR; Q765V4; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd08544; Reeler; 1.
DR   Gene3D; 2.60.40.4060; -; 1.
DR   InterPro; IPR002861; Reeler_dom.
DR   InterPro; IPR042307; Reeler_sf.
DR   Pfam; PF02014; Reeler; 1.
DR   PROSITE; PS51019; REELIN; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Immunity; Innate immunity;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..167
FT                   /note="Putative defense protein Hdd11-like"
FT                   /id="PRO_0000372774"
FT   DOMAIN          19..167
FT                   /note="Reelin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00363"
FT   DISULFID        28..105
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   167 AA;  17789 MW;  D4E0BED769506F0C CRC64;
     MMFTYVVAVA SVVALTSAYP TGAPPSACFD MIPGHAADVQ TVPAPYTITT AVSSVKAGHS
     IDVVISGKTP EDKMAGILLE ARQGDKIVGT WTVSPDDTFS QPLNCGEPNN AVTHKMHAKE
     LDRQTVSYPW TAPKDLEGDV VFKVTIVKSY AVFWVGIESA PVKVLSH