ID   DFP3_LONON              Reviewed;         233 AA.
AC   Q5MGE6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Defense protein 3;
DE            Short=DFP-3;
DE   Flags: Precursor;
OS   Lonomia obliqua (Moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Hemileucinae; Lonomia.
OX   NCBI_TaxID=304329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spicule;
RX   PubMed=16023793; DOI=10.1016/j.gene.2005.05.002;
RA   Veiga A.B.G., Ribeiro J.M.C., Guimaraes J.A., Francischetti I.M.B.;
RT   "A catalog for the transcripts from the venomous structures of the
RT   caterpillar Lonomia obliqua: identification of the proteins potentially
RT   involved in the coagulation disorder and hemorrhagic syndrome.";
RL   Gene 355:11-27(2005).
CC   -!- FUNCTION: Has antibacterial activity against both Gram-positive and
CC       Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR   EMBL; AY829840; AAV91454.1; -; mRNA.
DR   AlphaFoldDB; Q5MGE6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR005521; Attacin_C.
DR   InterPro; IPR005520; Attacin_N.
DR   Pfam; PF03769; Attacin_C; 1.
DR   Pfam; PF03768; Attacin_N; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..45
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000372777"
FT   CHAIN           46..233
FT                   /note="Defense protein 3"
FT                   /id="PRO_0000372778"
SQ   SEQUENCE   233 AA;  25053 MW;  73F7BF9E8853DDBB CRC64;
     MFGKFVLLAV LLVGVNSRYV IIEDPVYYIE DHELPEQWTS SRVRRDAHGA VTLNTDGTSG
     AVVKVPIAGS DKNIVSAIGS VDLTDRLKVG AATAGLAIDN VNGHGASITD THIPGFGDKL
     TAAGKINLIH NDNHDLTANA FATRNMPSIP LVPDFNTVGG GIDYMFKDKI GASASVAHTD
     LINRNDYSLG GKLNLFKTPD TSVDFNAGWK KFDTPVINSN WEPNFGFSLS KYF