ID   DFP_LOCMI               Reviewed;         172 AA.
AC   Q25313;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Putative defense protein;
DE   AltName: Full=Basic 19 kDa hemolymph protein;
DE   Flags: Precursor;
OS   Locusta migratoria (Migratory locust).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kanost M.R., Bradfield J.Y., Cook K.E., Locke J., Wells M.A., Wyatt G.R.;
RT   "Gene structure, cDNA sequence, and developmental regulation of a low
RT   molecular weight hemolymph protein from Locusta migratoria.";
RL   Arch. Insect Biochem. Physiol. 8:203-217(1988).
CC   -!- FUNCTION: May have antimicrobial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: In adults, in hemolymph.
CC   -!- INDUCTION: Its synthesis is positively regulated by juvenile hormone.
CC   -!- SIMILARITY: Belongs to the insect defense protein family.
CC       {ECO:0000305}.
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DR   EMBL; M36206; AAA29283.1; -; mRNA.
DR   AlphaFoldDB; Q25313; -.
DR   SMR; Q25313; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd08544; Reeler; 1.
DR   Gene3D; 2.60.40.4060; -; 1.
DR   InterPro; IPR002861; Reeler_dom.
DR   InterPro; IPR042307; Reeler_sf.
DR   Pfam; PF02014; Reeler; 1.
DR   PROSITE; PS51019; REELIN; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..172
FT                   /note="Putative defense protein"
FT                   /id="PRO_5000143299"
FT   DOMAIN          22..172
FT                   /note="Reelin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00363"
SQ   SEQUENCE   172 AA;  18807 MW;  2EC9611EADE4C626 CRC64;
     MKLVVAAVLA MAASRWRRLS AHGQVPSSTC ADMLPVHGNA MPSTALPYTI TVSPTSVNGG
     DTVRVHISGT EEFRGVYLQR GGAKSSRRVP AARRREQQDR PVRLPAGHNN AFSYISRTPL
     DTLDIDWKAP YTSDEIVFRA TFVKSFSEFW VGVESPKITL GPLRQLDNAV AA