ID   DFP_MANSE               Reviewed;         166 AA.
AC   Q86RS3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Putative defense protein Hdd11-like;
DE   Flags: Precursor;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Fat body;
RX   PubMed=12706633; DOI=10.1016/s0965-1748(03)00028-6;
RA   Zhu Y., Johnson T.J., Myers A.A., Kanost M.R.;
RT   "Identification by subtractive suppression hybridization of bacteria-
RT   induced genes expressed in Manduca sexta fat body.";
RL   Insect Biochem. Mol. Biol. 33:541-559(2003).
CC   -!- FUNCTION: May have antimicrobial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: In larvae, expressed in fat body.
CC       {ECO:0000269|PubMed:12706633}.
CC   -!- INDUCTION: In larvae, by bacteria. {ECO:0000269|PubMed:12706633}.
CC   -!- SIMILARITY: Belongs to the insect defense protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF413066; AAO21507.1; -; mRNA.
DR   AlphaFoldDB; Q86RS3; -.
DR   SMR; Q86RS3; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd08544; Reeler; 1.
DR   Gene3D; 2.60.40.4060; -; 1.
DR   InterPro; IPR002861; Reeler_dom.
DR   InterPro; IPR042307; Reeler_sf.
DR   Pfam; PF02014; Reeler; 1.
DR   PROSITE; PS51019; REELIN; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Glycoprotein; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..166
FT                   /note="Putative defense protein Hdd11-like"
FT                   /id="PRO_0000372773"
FT   DOMAIN          19..166
FT                   /note="Reelin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00363"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..105
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   166 AA;  18093 MW;  F93E8C923D20D068 CRC64;
     MWFTYTFAML LVAGYVSAYG SGAPQSACQD MIPRHPVGPQ NTSAPYIITT STKVVKAGTP
     MQVTISGKKP ENTMRGILLQ ARQGDKIVGK FTLDDNDSFA QLLDCGEPGN AITHKRHPPE
     FDKQTVTFTW TPPADLNDNI RFRATIAYSG AVFWLGVESP VVKVVA