DFSC1_CAEEL
ID DFSC1_CAEEL Reviewed; 310 AA.
AC Q93246;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Homeobox protein dsc-1 {ECO:0000303|PubMed:16236771};
DE AltName: Full=Defecation suppressor of clk-1 {ECO:0000303|PubMed:16236771};
GN Name=dsc-1 {ECO:0000312|EMBL:CAA20928.1, ECO:0000312|WormBase:C18B12.3};
GN ORFNames=C18B12.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000312|EMBL:CAA20928.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:CAA20928.1};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE,
RP AND MUTAGENESIS OF ARG-232.
RX PubMed=16236771; DOI=10.1242/dev.02069;
RA Branicky R., Hekimi S.;
RT "Specification of muscle neurotransmitter sensitivity by a Paired-like
RT homeodomain protein in Caenorhabditis elegans.";
RL Development 132:4999-5009(2005).
CC -!- FUNCTION: Transcriptional regulator which plays a role in the expulsion
CC step of defecation by controlling enteric muscle-specific expression of
CC exp-1 which is required for enteric muscle contraction. Not required
CC for exp-1 expression in the PDA neuron. Also involved in controlling
CC the length of the defecation cycle. {ECO:0000269|PubMed:16236771}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:16236771}. Cell projection, axon
CC {ECO:0000269|PubMed:16236771}. Cytoplasm {ECO:0000269|PubMed:16236771}.
CC -!- TISSUE SPECIFICITY: Expressed in the bilateral sensory neurons AWA,
CC AWB, AWC, ASE, FLP and PVD. Also expressed in the enteric intestinal
CC and anal depressor muscles. {ECO:0000269|PubMed:16236771}.
CC -!- DISRUPTION PHENOTYPE: Shortened defecation cycle length with change in
CC periodicity of the cycle. Expulsion defective with distended gut and
CC lack of enteric muscle contractions due to lack of exp-1 expression.
CC {ECO:0000269|PubMed:16236771}.
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DR EMBL; AL031620; CAA20928.1; -; Genomic_DNA.
DR PIR; T19379; T19379.
DR RefSeq; NP_510497.1; NM_078096.1.
DR AlphaFoldDB; Q93246; -.
DR SMR; Q93246; -.
DR BioGRID; 46496; 2.
DR IntAct; Q93246; 1.
DR STRING; 6239.C18B12.3; -.
DR PaxDb; Q93246; -.
DR EnsemblMetazoa; C18B12.3.1; C18B12.3.1; WBGene00001096.
DR EnsemblMetazoa; C18B12.3.2; C18B12.3.2; WBGene00001096.
DR GeneID; 181599; -.
DR KEGG; cel:CELE_C18B12.3; -.
DR UCSC; C18B12.3; c. elegans.
DR CTD; 181599; -.
DR WormBase; C18B12.3; CE08308; WBGene00001096; dsc-1.
DR eggNOG; KOG0494; Eukaryota.
DR GeneTree; ENSGT00940000160793; -.
DR HOGENOM; CLU_909838_0_0_1; -.
DR InParanoid; Q93246; -.
DR OMA; PASYYHN; -.
DR OrthoDB; 1014909at2759; -.
DR PhylomeDB; Q93246; -.
DR PRO; PR:Q93246; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001096; Expressed in larva and 1 other tissue.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0042995; C:cell projection; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:2000748; P:positive regulation of defecation rhythm; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cytoplasm; Differentiation; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..310
FT /note="Homeobox protein dsc-1"
FT /id="PRO_0000423537"
FT DNA_BIND 180..239
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 262..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 232
FT /note="R->H: In qm133; shortened defecation cycle length
FT and lack of enteric muscle contractions."
FT /evidence="ECO:0000269|PubMed:16236771"
SQ SEQUENCE 310 AA; 35309 MW; 7C9421B4A8A090EB CRC64;
MNPHTNLNNV FDFPDLPMLL PKSEALSVTT DFSVPPVQQG AQQFHPPRNL GPQLARRWSC
GDSQHADEPP ASYYHNLGVA LHNHFQMSNQ HYLSDFDCPT TVSPISSAHE TGQLPQLSPY
DHIGNQDPHM FSPHAYGNSM IPDNSYFENA SRSISAPNVG NSTLNPSLMS SDNAQSCGGR
RRFRTNFTEL QSTFLEDSFK ESHYPDHKAK KYMADFLKIP EDRITVWFQN RRAKWRRKEH
RQRDRTRNES FSGGSNSFDF ACFSAQHPDD GPNAKHPNSF GIPNQPMSLD QFPMNTEQDF
PEFPSLQEHQ
