ID   DG17_DICDI              Reviewed;         460 AA.
AC   P11467; Q54FC1;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=RING finger protein DG17;
DE   AltName: Full=Probable TNF receptor-associated factor DDB_G0290961;
GN   Name=zfaA; Synonyms=DG17; ORFNames=DDB_G0290961;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RX   PubMed=2830496; DOI=10.1128/mcb.7.12.4482-4489.1987;
RA   Driscoll D.M., Williams J.G.;
RT   "Two divergently transcribed genes of Dictyostelium discoideum are cyclic
RT   AMP-inducible and coregulated during development.";
RL   Mol. Cell. Biol. 7:4482-4489(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By cAMP during aggregation. {ECO:0000269|PubMed:2830496}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: The expression of DG17 protein is developmentally
CC       regulated.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M18106; AAA33192.1; -; Genomic_DNA.
DR   EMBL; AAFI02000174; EAL61911.1; -; Genomic_DNA.
DR   PIR; A29361; A29361.
DR   RefSeq; XP_635416.1; XM_630324.1.
DR   AlphaFoldDB; P11467; -.
DR   STRING; 44689.DDB0216198; -.
DR   PaxDb; P11467; -.
DR   EnsemblProtists; EAL61911; EAL61911; DDB_G0290961.
DR   GeneID; 8627917; -.
DR   KEGG; ddi:DDB_G0290961; -.
DR   dictyBase; DDB_G0290961; trafD.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; P11467; -.
DR   OMA; CQEVTIS; -.
DR   PhylomeDB; P11467; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:P11467; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 4.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF00917; MATH; 1.
DR   Pfam; PF02176; zf-TRAF; 2.
DR   SMART; SM00061; MATH; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50145; ZF_TRAF; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Developmental protein; Metal-binding;
KW   Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..460
FT                   /note="RING finger protein DG17"
FT                   /id="PRO_0000055896"
FT   DOMAIN          320..448
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         27..67
FT                   /note="RING-type"
FT   ZN_FING         141..194
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         196..253
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   COILED          269..294
FT                   /evidence="ECO:0000255"
FT   CONFLICT        116
FT                   /note="D -> V (in Ref. 1; AAA33192)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        121
FT                   /note="K -> N (in Ref. 1; AAA33192)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167..174
FT                   /note="LESHQNEC -> IKMNG (in Ref. 1; AAA33192)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        410
FT                   /note="K -> KR (in Ref. 1; AAA33192)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   460 AA;  53286 MW;  D8F6FA1FE90CD71E CRC64;
     MSIDIKFTIN DILFNQESLQ KKNKYTCPIC FEFIYKKQIY QCKSGHHACK ECWEKSLETK
     KECMTCKSVV NSYNDLSRCL MVERAFDKKE CCCIYSFNEQ IVEGGTNCSP PDGASDQNQR
     KLIKDEENGC KEKIEVDQID SHLINCQYKF VTCSFKGCEK ILRMNSLESH QNECGFKLVT
     CDFCKRDDIK KKELETHYKT CPMVPIDCSQ GCSVKIERKS IIDHIENDCC NTQIPCKYFE
     QGCKVEMKRS ELQNHLERVN HQNYMGILIE KLTNQVGQSK KTHDELLKKI EDLSLLVIKF
     SDACLKKQVL PKALDICSNG YRNKWIISNY SSVAKSKLNC QALSSPMLSI LSHLFQVCVY
     PKGDENKEYI SLYLRVNNIE EPNSLKVEYS FTLVNVLDKS KSITKKEDKK VFISSEGWGW
     GKFLLSDLIN KENGWLSNDD KLIIEIYIKI LNEEYEPLES