ID   DG2L6_BOVIN             Reviewed;         337 AA.
AC   A6QP72;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Diacylglycerol O-acyltransferase 2-like protein 6;
DE            EC=2.3.1.- {ECO:0000250|UniProtKB:Q6ZPD8};
GN   Name=DGAT2L6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Diglyceride acyltransferase that uses fatty acyl-CoA as
CC       substrate. Particularly active with oleate as a substrate. Has no wax
CC       synthase activity to produce wax esters.
CC       {ECO:0000250|UniProtKB:Q6ZPD8}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol =
CC         1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219,
CC         ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57387; Evidence={ECO:0000250|UniProtKB:Q6ZPD8};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the diacylglycerol acyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BC149181; AAI49182.1; -; mRNA.
DR   RefSeq; NP_001095331.2; NM_001101861.1.
DR   AlphaFoldDB; A6QP72; -.
DR   STRING; 9913.ENSBTAP00000010259; -.
DR   PaxDb; A6QP72; -.
DR   PRIDE; A6QP72; -.
DR   GeneID; 505958; -.
DR   KEGG; bta:505958; -.
DR   CTD; 347516; -.
DR   eggNOG; KOG0831; Eukaryota.
DR   HOGENOM; CLU_023995_0_0_1; -.
DR   InParanoid; A6QP72; -.
DR   OrthoDB; 1347007at2759; -.
DR   TreeFam; TF314707; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
DR   InterPro; IPR007130; DAGAT.
DR   Pfam; PF03982; DAGAT; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Endoplasmic reticulum; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="Diacylglycerol O-acyltransferase 2-like protein 6"
FT                   /id="PRO_0000320298"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   337 AA;  38327 MW;  23A44CBBAD6BFBF1 CRC64;
     MAFLSQLNLQ EILQTLSVLQ WMPVYVFLGA IPIIVIPYFL VFTKFWMVSV LALAWLAYDW
     NTHSQGGRRS AWVRNWTIWK YFQNYFPIKL VKTHDLSPRH NYIIASHPHG VLPYGTFINF
     ATETTGFARI FPGITPYVAT LEGIFWIPIV REYVMSMGVC PVSELALKYL LTQKGSGNAV
     VIMVGGGAEA LLCHPGATTV LLKQRKGFVK VALETGAYLV PSYSFGQNEV HNQETFPEGT
     WKRFFQKALQ DTLKKLLRLS VCTFHGRGLT RGSWGFLPFN HPITTVVGEP LPIPRIKKPN
     EETVDKYHAL YINALQKLFD EHKVQYGLSE TQELTII