ID   DG2L6_MOUSE             Reviewed;         337 AA.
AC   A2ADU8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Diacylglycerol O-acyltransferase 2-like protein 6;
DE            EC=2.3.1.- {ECO:0000250|UniProtKB:Q6ZPD8};
GN   Name=Dgat2l6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Diglyceride acyltransferase that uses fatty acyl-CoA as
CC       substrate. Particularly active with oleate as a substrate. Has no wax
CC       synthase activity to produce wax esters.
CC       {ECO:0000250|UniProtKB:Q6ZPD8}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol =
CC         1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219,
CC         ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57387; Evidence={ECO:0000250|UniProtKB:Q6ZPD8};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the diacylglycerol acyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AL671299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53147.1; -.
DR   RefSeq; NP_001107556.1; NM_001114084.1.
DR   AlphaFoldDB; A2ADU8; -.
DR   SMR; A2ADU8; -.
DR   STRING; 10090.ENSMUSP00000036845; -.
DR   iPTMnet; A2ADU8; -.
DR   PhosphoSitePlus; A2ADU8; -.
DR   PaxDb; A2ADU8; -.
DR   PRIDE; A2ADU8; -.
DR   ProteomicsDB; 277317; -.
DR   Antibodypedia; 13248; 44 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000037541; ENSMUSP00000036845; ENSMUSG00000067597.
DR   GeneID; 668257; -.
DR   KEGG; mmu:668257; -.
DR   UCSC; uc012hmt.1; mouse.
DR   CTD; 347516; -.
DR   MGI; MGI:3045268; Dgat2l6.
DR   VEuPathDB; HostDB:ENSMUSG00000067597; -.
DR   eggNOG; KOG0831; Eukaryota.
DR   GeneTree; ENSGT01030000234582; -.
DR   HOGENOM; CLU_023995_0_0_1; -.
DR   InParanoid; A2ADU8; -.
DR   OMA; GTWIRFF; -.
DR   OrthoDB; 1347007at2759; -.
DR   PhylomeDB; A2ADU8; -.
DR   TreeFam; TF314707; -.
DR   Reactome; R-MMU-1482883; Acyl chain remodeling of DAG and TAG.
DR   BioGRID-ORCS; 668257; 0 hits in 74 CRISPR screens.
DR   PRO; PR:A2ADU8; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; A2ADU8; protein.
DR   Bgee; ENSMUSG00000067597; Expressed in lip and 8 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; ISO:MGI.
DR   GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
DR   GO; GO:0006640; P:monoacylglycerol biosynthetic process; ISO:MGI.
DR   InterPro; IPR007130; DAGAT.
DR   Pfam; PF03982; DAGAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Endoplasmic reticulum; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="Diacylglycerol O-acyltransferase 2-like protein 6"
FT                   /id="PRO_0000320297"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   337 AA;  38362 MW;  B7EB67BB4C408D8A CRC64;
     MAAFSCLDLQ EGLRTLSILQ WIPVYVLLGT LSILGMPYLL LFTTLWPLSV LFLVWIAYDW
     NTHIQDGRRS AWVRNWTLWK YFQSYFPVKL VKTHDLSPKH NYIILSHPHG ILSYGAFINF
     ATESTGFSRV FPSITPFLAT LEGIFWIPFV RDYLMSLGIC PVSKLSLTHK LTQKDSGNAV
     IIVPGGASES LLSRPGVSMI YLKKRQGFVK LALKTGAYLV PSYSFGENET YNQETFAEGT
     WLRFFQKNIQ KIGKRILGIN LCTIHGRGLT RGSWGFLPFN HPITTVVGEP LPVPKIPDPD
     KETVEKYLEL YISALRKLFD QHKAEYGLSK THELKIL