ID   3CP1_STRS9              Reviewed;          21 AA.
AC   P37046; Q7M104;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 3.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Tricyclic peptide RP 71955 {ECO:0000303|PubMed:8286361};
OS   Streptomyces sp. (strain SP9440).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=72594;
RN   [1]
RP   PROTEIN SEQUENCE, STRUCTURE BY NMR, DISULFIDE BONDS, AND CROSS-LINK.
RX   PubMed=8286361; DOI=10.1021/bi00167a006;
RA   Frechet D., Guitton J.D., Herman F., Faucher D., Helynck G.,
RA   Monegier du Sorbier B., Ridoux J.P., James-Surcouf E., Vuilhorgne M.;
RT   "Solution structure of RP 71955, a new 21 amino acid tricyclic peptide
RT   active against HIV-1 virus.";
RL   Biochemistry 33:42-50(1994).
CC   -!- FUNCTION: Active against HIV-1 virus in vitro.
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DR   PIR; A53630; A53630.
DR   PDB; 1RPB; NMR; -; A=1-21.
DR   PDB; 1RPC; NMR; -; A=1-21.
DR   PDBsum; 1RPB; -.
DR   PDBsum; 1RPC; -.
DR   AlphaFoldDB; P37046; -.
DR   SMR; P37046; -.
DR   EvolutionaryTrace; P37046; -.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Thioether bond.
FT   PEPTIDE         1..21
FT                   /note="Tricyclic peptide RP 71955"
FT                   /evidence="ECO:0000269|PubMed:8286361"
FT                   /id="PRO_0000044214"
FT   DISULFID        1..13
FT                   /evidence="ECO:0000269|PubMed:8286361,
FT                   ECO:0007744|PDB:1RPB, ECO:0007744|PDB:1RPC"
FT   DISULFID        7..19
FT                   /evidence="ECO:0000269|PubMed:8286361,
FT                   ECO:0007744|PDB:1RPB, ECO:0007744|PDB:1RPC"
FT   CROSSLNK        1..9
FT                   /note="3-cysteinyl-aspartic acid (Cys-Asp)"
FT                   /evidence="ECO:0000269|PubMed:8286361"
FT   STRAND          5..7
FT                   /evidence="ECO:0007829|PDB:1RPB"
FT   STRAND          9..13
FT                   /evidence="ECO:0007829|PDB:1RPB"
FT   STRAND          15..18
FT                   /evidence="ECO:0007829|PDB:1RPB"
SQ   SEQUENCE   21 AA;  2186 MW;  EF94FAA21634FF91 CRC64;
     CLGIGSCNDF AGCGYAVVCF W