DGCR6_MOUSE
ID DGCR6_MOUSE Reviewed; 198 AA.
AC O35347; Q9D2P5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Protein DGCR6;
DE AltName: Full=DiGeorge syndrome critical region 6 homolog;
GN Name=Dgcr6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9605865; DOI=10.1159/000134736;
RA Lindsay E.A., Baldini A.;
RT "A mouse gene (Dgcr6) related to the Drosophila gonadal gene is expressed
RT in early embryogenesis and is the homolog of a human gene deleted in
RT DiGeorge syndrome.";
RL Cytogenet. Cell Genet. 79:243-247(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May have a role in early embryogenesis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O35347-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O35347-2; Sequence=VSP_001827, VSP_001828;
CC -!- TISSUE SPECIFICITY: Expressed in all the examined tissues with highest
CC expression in testis.
CC -!- DEVELOPMENTAL STAGE: Expressed in early embryogenesis. Found in the
CC peripheral and central nervous systems.
CC -!- SIMILARITY: Belongs to the gonadal family. {ECO:0000305}.
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DR EMBL; AF021031; AAB82548.1; -; mRNA.
DR EMBL; AK019346; BAB31671.1; -; mRNA.
DR CCDS; CCDS28016.1; -. [O35347-2]
DR CCDS; CCDS79433.1; -. [O35347-1]
DR RefSeq; NP_001276742.1; NM_001289813.1.
DR RefSeq; NP_034177.1; NM_010047.4.
DR AlphaFoldDB; O35347; -.
DR SMR; O35347; -.
DR PhosphoSitePlus; O35347; -.
DR MaxQB; O35347; -.
DR PaxDb; O35347; -.
DR PeptideAtlas; O35347; -.
DR PRIDE; O35347; -.
DR ProteomicsDB; 277319; -. [O35347-1]
DR ProteomicsDB; 277320; -. [O35347-2]
DR GeneID; 13353; -.
DR KEGG; mmu:13353; -.
DR CTD; 8214; -.
DR MGI; MGI:1202877; Dgcr6.
DR InParanoid; O35347; -.
DR OrthoDB; 1411665at2759; -.
DR BioGRID-ORCS; 13353; 1 hit in 57 CRISPR screens.
DR ChiTaRS; Dgcr6; mouse.
DR PRO; PR:O35347; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O35347; protein.
DR InterPro; IPR010849; Gonadal.
DR PANTHER; PTHR13054; PTHR13054; 1.
DR Pfam; PF07324; DGCR6; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..198
FT /note="Protein DGCR6"
FT /id="PRO_0000070261"
FT COILED 78..142
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..28
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_001827"
FT VAR_SEQ 29..36
FT /note="QSLVKELP -> MVESMAPA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_001828"
FT CONFLICT 190
FT /note="S -> G (in Ref. 2; BAB31671)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 198 AA; 22837 MW; 4767591BA0A95F14 CRC64;
MDRYAAAGDE AADRARQQER HYQLLSALQS LVKELPSSFQ QRLSYTTLSD LALALLDGTV
FEIVQGLLEI QHLTEKSLYN QRLRLQNEHR VLRQTLRQKH LEAQQSCRPH NLPVLQAAQQ
RELEAMEHRI REEQQAMDRK IVLELDRKVA DQQSTLEKAG VAGFYVTTNP QELTLQMNLL
ELIRKLQQRS CQVGKAAL
