ID   DGK5_CAEEL              Reviewed;         937 AA.
AC   Q10024; Q09588;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2003, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Putative diacylglycerol kinase K06A1.6;
DE            Short=DAG kinase;
DE            EC=2.7.1.107;
DE   AltName: Full=Diglyceride kinase;
DE            Short=DGK;
GN   Name=dgk-5; ORFNames=K06A1.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-
CC         phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:456216; EC=2.7.1.107;
CC   -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family.
CC       {ECO:0000305}.
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DR   EMBL; FO081583; CCD72614.1; -; Genomic_DNA.
DR   PIR; T16947; T16947.
DR   PIR; T34334; T34334.
DR   RefSeq; NP_495301.1; NM_062900.3.
DR   AlphaFoldDB; Q10024; -.
DR   SMR; Q10024; -.
DR   STRING; 6239.K06A1.6; -.
DR   iPTMnet; Q10024; -.
DR   EPD; Q10024; -.
DR   PaxDb; Q10024; -.
DR   PeptideAtlas; Q10024; -.
DR   EnsemblMetazoa; K06A1.6a.1; K06A1.6a.1; WBGene00019428.
DR   GeneID; 174068; -.
DR   CTD; 174068; -.
DR   WormBase; K06A1.6a; CE28048; WBGene00019428; dgk-5.
DR   eggNOG; KOG0782; Eukaryota.
DR   GeneTree; ENSGT00940000167477; -.
DR   HOGENOM; CLU_003770_4_1_1; -.
DR   InParanoid; Q10024; -.
DR   OMA; CTPNLMR; -.
DR   OrthoDB; 274339at2759; -.
DR   PhylomeDB; Q10024; -.
DR   Reactome; R-CEL-114508; Effects of PIP2 hydrolysis.
DR   PRO; PR:Q10024; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00019428; Expressed in larva and 3 other tissues.
DR   ExpressionAtlas; Q10024; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004143; F:diacylglycerol kinase activity; IBA:GO_Central.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:InterPro.
DR   GO; GO:0046339; P:diacylglycerol metabolic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0046834; P:lipid phosphorylation; IBA:GO_Central.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.50.10330; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR037607; DGK.
DR   InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   PANTHER; PTHR11255; PTHR11255; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00609; DAGK_acc; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00045; DAGKa; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; SSF111331; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..937
FT                   /note="Putative diacylglycerol kinase K06A1.6"
FT                   /id="PRO_0000218472"
FT   DOMAIN          414..551
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00783"
FT   REGION          44..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   937 AA;  105198 MW;  7F9FA163AF783790 CRC64;
     MIFPIGIPMI SKKRKSAQEA VSLREAAERR SQFARVPARS VSAPPRKKWF RSKQQLSGAA
     DGMDGSSRAG SQEIVCDEFT KKLVAAITTW HDIHSSLLQL SIERSSNDSN EEHENVSVSS
     ESSWSSASDS ESDEDSATGR DSTNNHLSAS AARFSISNPD LTNCQIKQMF PEMADHWRKA
     LAKSPVVRRT AADQETSNPV NKHRSSRYWI EDEGDYHILP SEHVWLPSST GSSASADSEC
     YVGEKDCRRS GEKRRCAACH IVAHTNCFSL LAKLNLNCKT TFRDYATKKT PSKESTDGLT
     AHHWVHKWRH EGRCNTCAKS FQQKMFFQGK EKKETIAVTC SWCKESYHLK NCFARDKLEE
     RCNRGALKEM IVPPTWILRL ANRKRSSRTP SHPRKHKKSH RQFVVKPTDL WSSGPSQPLL
     VFVNPKSGGN KGSKALHTLC WLLNPRQVFD ITSLKGPKFG LEMFRKVVTQ LRILVCGGDG
     TVGWVLSTLD NLNWPAYPPM AIMPLGTGND LARCMGWGGV FSDEPISQLM QAILHETIVT
     HLDRWRIDVE PNTSCNLEEE DDGMQSALPL TVMTNYFSIG ADAHVALQFH HSRSANPQML
     NSRLKNRIAY GGLGTIDLFK RSWKDLCEYI TLECDGVDVT PRIKELKLHC ILFHNITYYA
     GGTIPWGESS DNKPSCCDGK VEVLGFTTAT LAALQMGGKG ERIAQCSRVR VITNKAIPMQ
     VDGEPCLLAP SIITLGFHSK VPMLKREKKT PCTPNLMRRG TRYGQKDSQV QSTSLIIQLP
     VIVVGRADYD NYKDCFERLK DTAYEIGIVN VESEAELDSA RVLIQRLLVE HNSLPYEPDK
     NWRFLDYVSN AEEGTFRVSR QQEHVQSVSD VCNTDECLLI LDHAFPSITD REAVELFQPQ
     QPIPSTSTSA APRYHNSRRI SETLRIVLSS DAQETHL