ID   DGOK_ECOLI              Reviewed;         292 AA.
AC   P31459; Q2M806;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=2-dehydro-3-deoxygalactonokinase;
DE            EC=2.7.1.58;
DE   AltName: Full=2-keto-3-deoxy-galactonokinase;
DE   AltName: Full=2-oxo-3-deoxygalactonate kinase;
GN   Name=dgoK; Synonyms=yidV; OrderedLocusNames=b3693, JW3670;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7686882; DOI=10.1006/geno.1993.1230;
RA   Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.;
RT   "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome:
RT   organizational symmetry around the origin of replication.";
RL   Genomics 16:551-561(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   INDUCTION, OPERON, AND DISRUPTION PHENOTYPE.
RX   PubMed=30455279; DOI=10.1128/jb.00281-18;
RA   Singh B., Arya G., Kundu N., Sangwan A., Nongthombam S., Chaba R.;
RT   "Molecular and functional insights into the regulation of D-galactonate
RT   metabolism by the transcriptional regulator DgoR in Escherichia coli.";
RL   J. Bacteriol. 201:e00281-e00281(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-
CC         phospho-D-galactonate + ADP + H(+); Xref=Rhea:RHEA:16525,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57989,
CC         ChEBI:CHEBI:58298, ChEBI:CHEBI:456216; EC=2.7.1.58;
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-galactonate degradation; D-
CC       glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 2/3.
CC   -!- INDUCTION: Part of the dgoRKADT operon, which encodes proteins for the
CC       metabolism of D-galactonate (PubMed:30455279). Negatively regulated by
CC       DgoR (PubMed:30455279). Expression is induced in the presence of D-
CC       galactonate (PubMed:30455279). {ECO:0000269|PubMed:30455279}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant cannot grow on D-galactonate.
CC       {ECO:0000269|PubMed:30455279}.
CC   -!- SIMILARITY: Belongs to the DgoK family. {ECO:0000305}.
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DR   EMBL; L10328; AAA62045.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76716.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77600.1; -; Genomic_DNA.
DR   PIR; F65171; F65171.
DR   RefSeq; NP_418148.1; NC_000913.3.
DR   RefSeq; WP_000127091.1; NZ_SSZK01000035.1.
DR   AlphaFoldDB; P31459; -.
DR   SMR; P31459; -.
DR   BioGRID; 4263413; 153.
DR   IntAct; P31459; 3.
DR   STRING; 511145.b3693; -.
DR   PaxDb; P31459; -.
DR   PRIDE; P31459; -.
DR   DNASU; 948207; -.
DR   EnsemblBacteria; AAC76716; AAC76716; b3693.
DR   EnsemblBacteria; BAE77600; BAE77600; BAE77600.
DR   GeneID; 948207; -.
DR   KEGG; ecj:JW3670; -.
DR   KEGG; eco:b3693; -.
DR   PATRIC; fig|1411691.4.peg.3009; -.
DR   EchoBASE; EB1668; -.
DR   eggNOG; COG3734; Bacteria.
DR   HOGENOM; CLU_058005_2_0_6; -.
DR   InParanoid; P31459; -.
DR   OMA; RNGWIEM; -.
DR   PhylomeDB; P31459; -.
DR   BioCyc; EcoCyc:DEHYDDEOXGALACTKIN-MON; -.
DR   BioCyc; MetaCyc:DEHYDDEOXGALACTKIN-MON; -.
DR   UniPathway; UPA00081; UER00519.
DR   PRO; PR:P31459; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0008671; F:2-dehydro-3-deoxygalactonokinase activity; IDA:EcoCyc.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0034194; P:D-galactonate catabolic process; IMP:EcoCyc.
DR   Gene3D; 3.30.420.300; -; 1.
DR   Gene3D; 3.30.420.310; -; 1.
DR   InterPro; IPR007729; DGOK.
DR   InterPro; IPR042257; DGOK_C.
DR   InterPro; IPR042258; DGOK_N.
DR   Pfam; PF05035; DGOK; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..292
FT                   /note="2-dehydro-3-deoxygalactonokinase"
FT                   /id="PRO_0000079881"
SQ   SEQUENCE   292 AA;  31374 MW;  BBF5219EE27F35F9 CRC64;
     MTARYIAIDW GSTNLRAWLY QGDHCLESRQ SEAGVTRLNG KSPAAVLAEV TTDWREEKTP
     VVMAGMVGSN VGWKVAPYLS VPACFSSIGE QLTSVGDNIW IIPGLCVSHD DNHNVMRGEE
     TQLIGARALA PSSLYVMPGT HCKWVQADSQ QINDFRTVMT GELHHLLLNH SLIGAGLPPQ
     ENSADAFTAG LERGLNTPAI LPQLFEVRAS HVLGTLPREQ VSEFLSGLLI GAEVASMRDY
     VAHQHAITLV AGTSLTARYQ QAFQAMGCDV TAVAGDTAFQ AGIRSIAHAV AN