DGP10_ARATH
ID DGP10_ARATH Reviewed; 586 AA.
AC Q9FIV6;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protease Do-like 10, mitochondrial;
DE EC=3.4.21.-;
DE Flags: Precursor;
GN Name=DEGP10; OrderedLocusNames=At5g36950; ORFNames=MLF18_70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11299370; DOI=10.1104/pp.125.4.1912;
RA Adam Z., Adamska I., Nakabayashi K., Ostersetzer O., Haussuhl K.,
RA Manuell A., Zheng B., Vallon O., Rodermel S.R., Shinozaki K., Clarke A.K.;
RT "Chloroplast and mitochondrial proteases in Arabidopsis. A proposed
RT nomenclature.";
RL Plant Physiol. 125:1912-1918(2001).
CC -!- FUNCTION: Probable serine protease.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR EMBL; AB016877; BAB11638.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94131.1; -; Genomic_DNA.
DR EMBL; AY069888; AAL47441.1; -; mRNA.
DR EMBL; BT015174; AAT85770.1; -; mRNA.
DR RefSeq; NP_568543.1; NM_123053.5.
DR AlphaFoldDB; Q9FIV6; -.
DR SMR; Q9FIV6; -.
DR STRING; 3702.AT5G36950.1; -.
DR MEROPS; S01.A04; -.
DR PaxDb; Q9FIV6; -.
DR PRIDE; Q9FIV6; -.
DR ProteomicsDB; 224098; -.
DR EnsemblPlants; AT5G36950.1; AT5G36950.1; AT5G36950.
DR GeneID; 833665; -.
DR Gramene; AT5G36950.1; AT5G36950.1; AT5G36950.
DR KEGG; ath:AT5G36950; -.
DR Araport; AT5G36950; -.
DR TAIR; locus:2167468; AT5G36950.
DR eggNOG; KOG1320; Eukaryota.
DR HOGENOM; CLU_020120_10_2_1; -.
DR InParanoid; Q9FIV6; -.
DR OMA; FRVGECG; -.
DR OrthoDB; 594175at2759; -.
DR PhylomeDB; Q9FIV6; -.
DR PRO; PR:Q9FIV6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIV6; baseline and differential.
DR Genevisible; Q9FIV6; AT.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.10; -; 2.
DR InterPro; IPR041517; DEGP_PDZ.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF17815; PDZ_3; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Mitochondrion; Protease; Reference proteome; Serine protease;
KW Transit peptide.
FT TRANSIT 1..22
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 23..586
FT /note="Protease Do-like 10, mitochondrial"
FT /id="PRO_0000045834"
FT DOMAIN 318..398
FT /note="PDZ"
FT REGION 60..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..302
FT /note="Serine protease"
FT COMPBIAS 60..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 156
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT ACT_SITE 187
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT ACT_SITE 265
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
SQ SEQUENCE 586 AA; 64726 MW; 908147EE6B4B6836 CRC64;
MLLRSFRTVE LLRRISTSSV SGYRTSPSLL QRCNGFQSYL PHRVTTTESP FPSHISRFCS
SQSANSQNEN RHTTLSSPVS SRRVNNRKIS RRRKAGKSLS ISPAADAVDL ALDSVVKIFT
VSTSPSYFLP WQNKSQRESM GSGFVISGRK IITNAHVVAD HSFVLVRKHG SSIKHRAEVQ
AVGHECDLAI LVVDSEVFWE GMNALELGDI PFLQEAVAVV GYPQGGDNIS VTKGVVSRVE
PTQYVHGATQ LMAIQIDAAI NPGNSGGPAI MGNKVAGVAF QNLSGAENIG YIIPTPVIKH
FINGVEECGK YIGFCSMGVS CQPMENGELR SGFQMSSEMT GVLVSKINPL SDAHKILKKD
DVLLAFDGVP IANDGTVPFR NRERITFDHL VSMKKPDETA LVKVLREGKE HEFSITLRPL
QPLVPVHQFD QLPSYYIFAG FVFVPLTQPY LHEYGEDWYN TSPRTLCHRA LKDLPKKAGQ
QLVIVSQVLM DDINTGYERL AELQVNKVNG VEVNNLRHLC QLIENCNTEK LRIDLDDESR
VIVLNYQSAK IATSLILKRH RIASAISSDL LIEQNLETEL ASCSAV
