ID   DGR1_YEAST              Reviewed;          48 AA.
AC   Q3E808; D6W153;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=2-deoxy-glucose resistant protein 1, mitochondrial;
DE   Flags: Precursor;
GN   Name=DGR1; OrderedLocusNames=YNL130C-A;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169873;
RA   Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA   Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA   Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA   Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA   Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA   Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA   Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA   Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA   Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA   Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA   Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA   Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA   Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA   Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA   Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA   Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA   Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT   evolutionary implications.";
RL   Nature 387:93-98(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12566404; DOI=10.1101/gr.232903;
RA   Kessler M.M., Zeng Q., Hogan S., Cook R., Morales A.J., Cottarel G.;
RT   "Systematic discovery of new genes in the Saccharomyces cerevisiae
RT   genome.";
RL   Genome Res. 13:264-271(2003).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19004802; DOI=10.1073/pnas.0803090105;
RA   Ralser M., Wamelink M.M., Struys E.A., Joppich C., Krobitsch S., Jakobs C.,
RA   Lehrach H.;
RT   "A catabolic block does not sufficiently explain how 2-deoxy-D-glucose
RT   inhibits cell growth.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:17807-17811(2008).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Increases cellular tolerance to 2-deoxy-glucose.
CC       {ECO:0000269|PubMed:19004802}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z71405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006947; DAA10419.1; -; Genomic_DNA.
DR   RefSeq; NP_878154.1; NM_001184574.1.
DR   AlphaFoldDB; Q3E808; -.
DR   BioGRID; 37054; 23.
DR   STRING; 4932.YNL130C-A; -.
DR   PaxDb; Q3E808; -.
DR   PRIDE; Q3E808; -.
DR   EnsemblFungi; YNL130C-A_mRNA; YNL130C-A; YNL130C-A.
DR   GeneID; 1466512; -.
DR   KEGG; sce:YNL130C-A; -.
DR   SGD; S000028579; DGR1.
DR   VEuPathDB; FungiDB:YNL130C-A; -.
DR   HOGENOM; CLU_3160240_0_0_1; -.
DR   BioCyc; YEAST:G3O-33409-MON; -.
DR   PRO; PR:Q3E808; -.
DR   Proteomes; UP000002311; Chromosome XIV.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..28
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..48
FT                   /note="2-deoxy-glucose resistant protein 1, mitochondrial"
FT                   /id="PRO_0000247800"
SQ   SEQUENCE   48 AA;  5609 MW;  2985F70956A12ED7 CRC64;
     MQVGFVSQTN CRSFPACIVF LFQMSQRQRS FNANLRVFKS KCKKIYIG