DGT1A_VIBCH
ID DGT1A_VIBCH Reviewed; 441 AA.
AC Q9KQL9;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase-like protein 1 {ECO:0000255|HAMAP-Rule:MF_01212};
GN OrderedLocusNames=VC_1979;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- SIMILARITY: Belongs to the dGTPase family. Type 2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01212}.
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DR EMBL; AE003852; AAF95127.1; -; Genomic_DNA.
DR PIR; B82132; B82132.
DR RefSeq; NP_231613.1; NC_002505.1.
DR RefSeq; WP_001198176.1; NZ_LT906614.1.
DR PDB; 7LWZ; X-ray; 2.32 A; A/B/C/D/E/F=2-441.
DR PDBsum; 7LWZ; -.
DR AlphaFoldDB; Q9KQL9; -.
DR SMR; Q9KQL9; -.
DR STRING; 243277.VC_1979; -.
DR DNASU; 2613483; -.
DR EnsemblBacteria; AAF95127; AAF95127; VC_1979.
DR GeneID; 57740604; -.
DR KEGG; vch:VC_1979; -.
DR PATRIC; fig|243277.26.peg.1891; -.
DR eggNOG; COG0232; Bacteria.
DR HOGENOM; CLU_028163_0_0_6; -.
DR OMA; KLAECGD; -.
DR BioCyc; VCHO:VC1979-MON; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0008832; F:dGTPase activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006203; P:dGTP catabolic process; IBA:GO_Central.
DR CDD; cd00077; HDc; 1.
DR HAMAP; MF_01212; dGTPase_type2; 1.
DR InterPro; IPR006261; dNTPase.
DR InterPro; IPR020779; dNTPase_1.
DR InterPro; IPR023023; dNTPase_2.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR026875; PHydrolase_assoc_dom.
DR PANTHER; PTHR11373:SF32; PTHR11373:SF32; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF13286; HD_assoc; 1.
DR SMART; SM00471; HDc; 1.
DR TIGRFAMs; TIGR01353; dGTP_triPase; 1.
DR PROSITE; PS51831; HD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Hydrolase; Reference proteome.
FT CHAIN 1..441
FT /note="Deoxyguanosinetriphosphate triphosphohydrolase-like
FT protein 1"
FT /id="PRO_0000205323"
FT DOMAIN 62..255
FT /note="HD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
FT HELIX 7..10
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 27..36
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 39..42
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 43..45
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 62..83
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 85..87
FT /evidence="ECO:0007829|PDB:7LWZ"
FT TURN 88..90
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 94..103
FT /evidence="ECO:0007829|PDB:7LWZ"
FT TURN 104..107
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 112..122
FT /evidence="ECO:0007829|PDB:7LWZ"
FT TURN 123..127
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 131..140
FT /evidence="ECO:0007829|PDB:7LWZ"
FT STRAND 146..149
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 155..161
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 188..191
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 199..201
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 202..209
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 214..220
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 241..264
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 270..282
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 287..300
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 305..320
FT /evidence="ECO:0007829|PDB:7LWZ"
FT STRAND 323..327
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 335..338
FT /evidence="ECO:0007829|PDB:7LWZ"
FT STRAND 339..343
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 345..362
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 366..388
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 390..393
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 396..406
FT /evidence="ECO:0007829|PDB:7LWZ"
FT TURN 407..409
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 411..420
FT /evidence="ECO:0007829|PDB:7LWZ"
FT HELIX 424..435
FT /evidence="ECO:0007829|PDB:7LWZ"
SQ SEQUENCE 441 AA; 49950 MW; F395B02C0980E506 CRC64;
MQVSLNPEWL ARNNDEHKIR RNDHRSPFQR DRARILHSAA FRRLQAKTQV HGTSLNDFHR
TRLTHSLEAA QIGTGIVAQI KLKQPEFREL LPSDSLIDSL CLAHDIGHPP YGHGGEIALN
YMMRDHGGFE GNAQTFRIVT SLEPYTEHHG MNLSRRTLLG LLKYPALLSA TRAAIPPPAV
AHQRQLKAKD WSPAKGIYDC DLASLDWVLE PLCESDRELL GQMRAEPSSP KEHRKTRFKS
LDCSIMELAD DIAYGVHDLE DAIVLGMVTR AQWQEAAAAQ LAECGDPWFE EHIAELSEML
FSGKHYVRKD AIGGIVNALL TSISVKPVEA PFHNELLAFN AYIEPHMGNA LEVLKHFVSQ
YVIQIPQVQR FEYKGQQLIM DLFEALSADP ERLLPQATGE KWRKAQEQDE GMRVICDYIA
AMTDAYAQRL HQQLFSAQSH Y
