ID   DGTL1_HAEI8             Reviewed;         461 AA.
AC   Q4QK52;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase-like protein {ECO:0000255|HAMAP-Rule:MF_01212};
GN   OrderedLocusNames=NTHI1825;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- SIMILARITY: Belongs to the dGTPase family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01212}.
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DR   EMBL; CP000057; AAX88595.1; -; Genomic_DNA.
DR   RefSeq; WP_005659555.1; NC_007146.2.
DR   AlphaFoldDB; Q4QK52; -.
DR   SMR; Q4QK52; -.
DR   EnsemblBacteria; AAX88595; AAX88595; NTHI1825.
DR   KEGG; hit:NTHI1825; -.
DR   HOGENOM; CLU_028163_0_0_6; -.
DR   OMA; KLAECGD; -.
DR   OrthoDB; 370035at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0008832; F:dGTPase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006203; P:dGTP catabolic process; IEA:InterPro.
DR   HAMAP; MF_01212; dGTPase_type2; 1.
DR   InterPro; IPR006261; dNTPase.
DR   InterPro; IPR020779; dNTPase_1.
DR   InterPro; IPR023023; dNTPase_2.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR026875; PHydrolase_assoc_dom.
DR   PANTHER; PTHR11373:SF32; PTHR11373:SF32; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF13286; HD_assoc; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR01353; dGTP_triPase; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..461
FT                   /note="Deoxyguanosinetriphosphate triphosphohydrolase-like
FT                   protein"
FT                   /id="PRO_1000073113"
FT   DOMAIN          72..285
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
FT   REGION          22..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   461 AA;  53324 MW;  F78F36D35A7B700A CRC64;
     MQKNEIKQSD MKPLIIDSSW TERFLPDPPR EKDNRPPFRR DRGRILHSAA FRCLQAKTQI
     HAIGENDFYR TRLTHSLEVA QIGSSLVAQL KFLETFESLS QTLNIDKNEL QKQLKPLLPS
     NDLIESLCFA HDIGHPPFGH GGETALNYMM AEQGGFEGNA QTFRILTKLE PYTENAGMNL
     TRRTLLGVVK YPALLGVASP QYAELNFSRN IDPRFVRIHD WIPGKGIFRD DLKMFNWLLE
     NLSENDRTLF CQFKKVRENP AESLHTRFKS LDCSIMELAD DIAYGVHDLE DAIVTGVVNP
     HQWQAAHVAL KQIPSAWLHE NIDSISQRLF SDKHFERKQA IGALVNFFIT NVRWKLTANF
     DEPLLRYNAE LPPEVIAALG VFKKFVWDYV IRNVDTQRIE YKGQRMLTEM FQIFESDPER
     LLPRNTENRW RNAPKEGKKR IICDYIAGMS DAHALRVYQQ L