ID   DGTL1_LEPIC             Reviewed;         381 AA.
AC   Q72RS7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase-like protein {ECO:0000255|HAMAP-Rule:MF_01212};
GN   OrderedLocusNames=LIC_11663;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS   (strain Fiocruz L1-130).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=267671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fiocruz L1-130;
RX   PubMed=15028702; DOI=10.1128/jb.186.7.2164-2172.2004;
RA   Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B.,
RA   Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA   Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L.,
RA   Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.T.,
RA   Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA   Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M.,
RA   Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L.,
RA   Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A.,
RA   Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A.,
RA   Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT   "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT   insights into physiology and pathogenesis.";
RL   J. Bacteriol. 186:2164-2172(2004).
CC   -!- SIMILARITY: Belongs to the dGTPase family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01212}.
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DR   EMBL; AE016823; AAS70256.1; -; Genomic_DNA.
DR   RefSeq; WP_000273947.1; NC_005823.1.
DR   AlphaFoldDB; Q72RS7; -.
DR   SMR; Q72RS7; -.
DR   PaxDb; Q72RS7; -.
DR   EnsemblBacteria; AAS70256; AAS70256; LIC_11663.
DR   GeneID; 61141565; -.
DR   KEGG; lic:LIC_11663; -.
DR   HOGENOM; CLU_028163_1_0_12; -.
DR   OMA; HCKAFRR; -.
DR   Proteomes; UP000007037; Chromosome I.
DR   GO; GO:0016793; F:triphosphoric monoester hydrolase activity; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_01212; dGTPase_type2; 1.
DR   InterPro; IPR006261; dNTPase.
DR   InterPro; IPR023023; dNTPase_2.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR026875; PHydrolase_assoc_dom.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF13286; HD_assoc; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR01353; dGTP_triPase; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..381
FT                   /note="Deoxyguanosinetriphosphate triphosphohydrolase-like
FT                   protein"
FT                   /id="PRO_0000205305"
FT   DOMAIN          76..203
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   381 AA;  44416 MW;  BB117C4691C4F967 CRC64;
     MYFSRDDLLQ KETETLAPYA ISNANNGGRI YEEEEHSYRL PFQRDRDRIL HSSAFKRLQY
     KTQVFIFSVG ENYRNRMTHT LEVAGLSRTI ASALGLNSLL SESIALAHDL GHTPFGHAGQ
     EILSGLMKDY GGFEHNKQSL RIVTSIEKKY PNFPGLNLCR ETLKGLMKHG ADYDSSVILL
     ERKENGPSLE GMIADLSDEI AYTNHDIEDG WEMGYLHLGD LLENPFWKEV YEECKDQYKE
     VGEKILIRTS IRTLTNFLVS DLIQNIAHRL EKKQIKSTED LALLWKQDFR IASFSKEVDL
     KFRELKSFLY EKLYRHEDLI RMSDYGKKII ESLFDYFLKH PEKIPDTYKE RIEEESLYRV
     ISDYVAGMTD RYAEKIYQSL P