ID   DGTL1_LEPIN             Reviewed;         381 AA.
AC   Q8F3X5;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase-like protein {ECO:0000255|HAMAP-Rule:MF_01212};
GN   OrderedLocusNames=LA_2274;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- SIMILARITY: Belongs to the dGTPase family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01212}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN49473.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE010300; AAN49473.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_712455.2; NC_004342.2.
DR   RefSeq; WP_000273947.1; NC_004342.2.
DR   AlphaFoldDB; Q8F3X5; -.
DR   SMR; Q8F3X5; -.
DR   STRING; 189518.LA_2274; -.
DR   EnsemblBacteria; AAN49473; AAN49473; LA_2274.
DR   GeneID; 61141565; -.
DR   KEGG; lil:LA_2274; -.
DR   PATRIC; fig|189518.3.peg.2261; -.
DR   HOGENOM; CLU_028163_1_0_12; -.
DR   InParanoid; Q8F3X5; -.
DR   OMA; HCKAFRR; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0008832; F:dGTPase activity; IBA:GO_Central.
DR   GO; GO:0006203; P:dGTP catabolic process; IBA:GO_Central.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_01212; dGTPase_type2; 1.
DR   InterPro; IPR006261; dNTPase.
DR   InterPro; IPR023023; dNTPase_2.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR026875; PHydrolase_assoc_dom.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF13286; HD_assoc; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR01353; dGTP_triPase; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..381
FT                   /note="Deoxyguanosinetriphosphate triphosphohydrolase-like
FT                   protein"
FT                   /id="PRO_0000205306"
FT   DOMAIN          76..203
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   381 AA;  44416 MW;  BB117C4691C4F967 CRC64;
     MYFSRDDLLQ KETETLAPYA ISNANNGGRI YEEEEHSYRL PFQRDRDRIL HSSAFKRLQY
     KTQVFIFSVG ENYRNRMTHT LEVAGLSRTI ASALGLNSLL SESIALAHDL GHTPFGHAGQ
     EILSGLMKDY GGFEHNKQSL RIVTSIEKKY PNFPGLNLCR ETLKGLMKHG ADYDSSVILL
     ERKENGPSLE GMIADLSDEI AYTNHDIEDG WEMGYLHLGD LLENPFWKEV YEECKDQYKE
     VGEKILIRTS IRTLTNFLVS DLIQNIAHRL EKKQIKSTED LALLWKQDFR IASFSKEVDL
     KFRELKSFLY EKLYRHEDLI RMSDYGKKII ESLFDYFLKH PEKIPDTYKE RIEEESLYRV
     ISDYVAGMTD RYAEKIYQSL P