ID   DGTL1_MYCBO             Reviewed;         431 AA.
AC   P0A541; A0A1R3Y1Q8; P95240; X2BKT4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase-like protein {ECO:0000255|HAMAP-Rule:MF_01212};
GN   Name=dgt; OrderedLocusNames=BQ2027_MB2373C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SIMILARITY: Belongs to the dGTPase family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01212}.
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DR   EMBL; LT708304; SIU00985.1; -; Genomic_DNA.
DR   RefSeq; NP_856022.1; NC_002945.3.
DR   RefSeq; WP_003899281.1; NC_002945.4.
DR   AlphaFoldDB; P0A541; -.
DR   SMR; P0A541; -.
DR   EnsemblBacteria; SIU00985; SIU00985; BQ2027_MB2373C.
DR   GeneID; 45426329; -.
DR   PATRIC; fig|233413.5.peg.2605; -.
DR   OMA; FGVYEDD; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0008832; F:dGTPase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006203; P:dGTP catabolic process; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_01212; dGTPase_type2; 1.
DR   InterPro; IPR006261; dNTPase.
DR   InterPro; IPR020779; dNTPase_1.
DR   InterPro; IPR023023; dNTPase_2.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR026875; PHydrolase_assoc_dom.
DR   PANTHER; PTHR11373:SF32; PTHR11373:SF32; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF13286; HD_assoc; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR01353; dGTP_triPase; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..431
FT                   /note="Deoxyguanosinetriphosphate triphosphohydrolase-like
FT                   protein"
FT                   /id="PRO_0000205307"
FT   DOMAIN          72..222
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   431 AA;  46912 MW;  75796A692301B0A2 CRC64;
     MSASEHDPYD DFDRQRRVAE APKTAGLPGT EGQYRSDFAR DRARVLHSAA LRRLADKTQV
     VGPREGDTPR TRLTHSLEVA QIGRGMAIGL GCDLDLVELA GLAHDIGHPP YGHNGERALD
     EVAASHGGFE GNAQNFRILT SLEPKVVDAQ GLSAGLNLTR ASLDAVTKYP WMRGDGLGSQ
     RRKFGFYDDD RESAVWVRQG APPERACLEA QVMDWADDVA YSVHDVEDGV VSERIDLRVL
     AAEEDAAALA RLGEREFSRV SADELMAAAR RLSRLPVVAA VGKYDATLSA SVALKRLTSE
     LVGRFASAAI ATTRAAAGPG PLVRFRADLQ VPDLVRAEVA VLKILALQFI MSDPRHLETQ
     ARQRERIHRV AHRLYSGAPQ TLDPVYAAAF NTAADDAARL RVVVDQIASY TEGRLERIDA
     DQLGVSRNAL D