ID   DGTL1_MYCS2             Reviewed;         428 AA.
AC   O52199; A0R0R7; I7GCA1;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase-like protein {ECO:0000255|HAMAP-Rule:MF_01212};
GN   Name=dgt; OrderedLocusNames=MSMEG_4483, MSMEI_4372;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9422594; DOI=10.1128/jb.180.1.65-72.1998;
RA   Klann A.G., Belanger A.E., Abanes-De Mello A., Lee J.Y., Hatfull G.F.;
RT   "Characterization of the dnaG locus in Mycobacterium smegmatis reveals
RT   linkage of DNA replication and cell division.";
RL   J. Bacteriol. 180:65-72(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- SIMILARITY: Belongs to the dGTPase family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01212}.
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DR   EMBL; AF027507; AAB96634.1; -; Genomic_DNA.
DR   EMBL; CP000480; ABK72246.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP40826.1; -; Genomic_DNA.
DR   RefSeq; WP_003895838.1; NZ_SIJM01000026.1.
DR   RefSeq; YP_888755.1; NC_008596.1.
DR   AlphaFoldDB; O52199; -.
DR   SMR; O52199; -.
DR   STRING; 246196.MSMEI_4372; -.
DR   EnsemblBacteria; ABK72246; ABK72246; MSMEG_4483.
DR   EnsemblBacteria; AFP40826; AFP40826; MSMEI_4372.
DR   GeneID; 66735815; -.
DR   KEGG; msg:MSMEI_4372; -.
DR   KEGG; msm:MSMEG_4483; -.
DR   PATRIC; fig|246196.19.peg.4389; -.
DR   eggNOG; COG0232; Bacteria.
DR   OMA; FGVYEDD; -.
DR   OrthoDB; 370035at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0008832; F:dGTPase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006203; P:dGTP catabolic process; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_01212; dGTPase_type2; 1.
DR   InterPro; IPR006261; dNTPase.
DR   InterPro; IPR020779; dNTPase_1.
DR   InterPro; IPR023023; dNTPase_2.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR026875; PHydrolase_assoc_dom.
DR   PANTHER; PTHR11373:SF32; PTHR11373:SF32; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF13286; HD_assoc; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR01353; dGTP_triPase; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..428
FT                   /note="Deoxyguanosinetriphosphate triphosphohydrolase-like
FT                   protein"
FT                   /id="PRO_0000205309"
FT   DOMAIN          72..222
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   428 AA;  46744 MW;  C7475B2A0DFD38DE CRC64;
     MNATQYDHYD DFDRERLVPE PAKSAALPGT DTEHRTDFAR DRARVLHCAA LRRLADKTQV
     VGPRHGDNPR TRLTHSLEVA QIGRGMAIGL GCDPDLVDLA GLAHDIGHPP YGHNGERALN
     EIAKAFGGFE GNAQNFRILT RLEPKVLDAD GRSAGLNLTR ASLDAVTKYP WRRTEERRKF
     GFYVGFPDDD GPAADWVRDG APVDRPCLEA QVMDWADDVA YSVHDVEDGV ISGRIDLRVL
     ADADAAESLA QLGAAAFPSL AHDDLLAAAQ RLSEMPVVAA VGKYDGTLAA SVALKRLTSE
     LVGRFANAAI TETRAVAGDR PLKRFDSDLV VPDLVRAEVA VLKMLALQFI MSDHQHLQVQ
     ADQRTRIHEV ALALWAQAPG SLDPQFAPEF AAAGDDGARL RVVIDQIASY TETRLERVHE
     ARSPRPLE