ID   DGTL1_NEOSM             Reviewed;         385 AA.
AC   Q2GDV1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase-like protein {ECO:0000255|HAMAP-Rule:MF_01212};
GN   OrderedLocusNames=NSE_0460;
OS   Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia
OS   sennetsu).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Neorickettsia.
OX   NCBI_TaxID=222891;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-367 / Miyayama;
RX   PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA   Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA   Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA   Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C.,
RA   Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D.,
RA   Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA   Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT   "Comparative genomics of emerging human ehrlichiosis agents.";
RL   PLoS Genet. 2:208-222(2006).
CC   -!- SIMILARITY: Belongs to the dGTPase family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01212}.
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DR   EMBL; CP000237; ABD46434.1; -; Genomic_DNA.
DR   RefSeq; WP_011451851.1; NC_007798.1.
DR   AlphaFoldDB; Q2GDV1; -.
DR   SMR; Q2GDV1; -.
DR   STRING; 222891.NSE_0460; -.
DR   EnsemblBacteria; ABD46434; ABD46434; NSE_0460.
DR   KEGG; nse:NSE_0460; -.
DR   eggNOG; COG0232; Bacteria.
DR   HOGENOM; CLU_028163_1_0_5; -.
DR   OMA; HCKAFRR; -.
DR   OrthoDB; 370035at2; -.
DR   Proteomes; UP000001942; Chromosome.
DR   GO; GO:0016793; F:triphosphoric monoester hydrolase activity; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_01212; dGTPase_type2; 1.
DR   InterPro; IPR006261; dNTPase.
DR   InterPro; IPR023023; dNTPase_2.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR026875; PHydrolase_assoc_dom.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF13286; HD_assoc; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR01353; dGTP_triPase; 1.
DR   TIGRFAMs; TIGR00277; HDIG; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..385
FT                   /note="Deoxyguanosinetriphosphate triphosphohydrolase-like
FT                   protein"
FT                   /id="PRO_1000164734"
FT   DOMAIN          62..197
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   385 AA;  45172 MW;  46FE3CFEF77E3C0E CRC64;
     MLSSYSSFPE RSKGRLFLEK EDPQRDCYQR DRDRLIHSSA FRRLMYKTQV FSHCGDDHYR
     TRLTHSLEVA QIARSIARLL GLNEDLTETI ALAHDIGHPP FAHIGEEALQ EVAAEHYRFE
     HNAQVLRILG EFEHQYMDFD GLNLTWETIE GLAKHNGPIQ EPHQIIEEYN GLLDLELNKQ
     PSLEAQIVSL ADDIAYSSHD IDDGLLSGVI TYQDLRHLPI IGENILKFEK TFPEASKSQV
     MYKARRRMIR FLIYDVVDVA RENIKRYLLK TVDDIRELGF PAANFSEKVG KEMKEIKAFL
     YNNLYFYYSI RKSRVKLKRI VKELFEVFFH DPQCLPKDYY ERFRIADSMN KKAQLVCDFI
     ANLTDSSAIR EHRQFFSTCV LERDY