ID   DGTL1_STRAW             Reviewed;         450 AA.
AC   Q82BN0;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Deoxyguanosinetriphosphate triphosphohydrolase-like protein {ECO:0000255|HAMAP-Rule:MF_01212};
GN   Name=dgt; OrderedLocusNames=SAV_5674;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- SIMILARITY: Belongs to the dGTPase family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01212}.
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DR   EMBL; BA000030; BAC73386.1; -; Genomic_DNA.
DR   RefSeq; WP_010987076.1; NZ_JZJK01000057.1.
DR   AlphaFoldDB; Q82BN0; -.
DR   SMR; Q82BN0; -.
DR   STRING; 227882.SAV_5674; -.
DR   EnsemblBacteria; BAC73386; BAC73386; SAVERM_5674.
DR   KEGG; sma:SAVERM_5674; -.
DR   eggNOG; COG0232; Bacteria.
DR   HOGENOM; CLU_028163_0_1_11; -.
DR   OMA; FGVYEDD; -.
DR   OrthoDB; 370035at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0008832; F:dGTPase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006203; P:dGTP catabolic process; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   HAMAP; MF_01212; dGTPase_type2; 1.
DR   InterPro; IPR006261; dNTPase.
DR   InterPro; IPR020779; dNTPase_1.
DR   InterPro; IPR023023; dNTPase_2.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR026875; PHydrolase_assoc_dom.
DR   PANTHER; PTHR11373:SF32; PTHR11373:SF32; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF13286; HD_assoc; 1.
DR   SMART; SM00471; HDc; 1.
DR   TIGRFAMs; TIGR01353; dGTP_triPase; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..450
FT                   /note="Deoxyguanosinetriphosphate triphosphohydrolase-like
FT                   protein"
FT                   /id="PRO_0000205320"
FT   DOMAIN          90..246
FT                   /note="HD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ   SEQUENCE   450 AA;  49506 MW;  E3F804C147718901 CRC64;
     MEGTTPGTPQ AYEDYEETVS YEDAVTRVGY DESAVERWAV EPDKRPGRTA FQRDRARVLH
     SSALRRLAGK TQVVTPGTRS RAWDASPRTR LTHSLECAQV GRELGAALGC DPDLVEAACL
     SHDLGHPPFG HNGEQALNEF AEDCGGFEGN AQSLRLLARI EPKRFVRSEG SGELVSVGLN
     LTRAALDAAT KYPWPRRAHP TDPTSPKFGV YEDDRPVFDW IRKGAPGHRT CFEAQVMDWA
     DDVAYSVHDV EDGLHAGHID PNCLHAEPER QAVFAVAIGR YVPADTDPAE LAEALDRLLD
     QEWWPHGYDG SAVAQARLKD ATSQLIGRFC LAAEGATRAA YGSGRLTRYA AELVVPRAAR
     LECAVLKAVA DWYVMQRAEQ ERLRADQRVV VAELAEALTA RAPEGLDPQF WALFDEAADD
     RARKRVIVDQ IASLTDVAAR SLHARLTGHL